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Open Imaging Index
MRI Brain

UCLA CNP (ds000030)

UCLA Consortium for Neuropsychiatric Phenomics LA5c Study

Brain MRI of 272 adults aged 21 to 50 from Los Angeles: healthy controls and people with schizophrenia, bipolar disorder or ADHD, with T1w, 64-direction diffusion, resting-state and seven task fMRI scans, in BIDS under CC0.

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Overview

The Consortium for Neuropsychiatric Phenomics (CNP) at UCLA studied memory and response inhibition across healthy adults and several psychiatric diagnoses. Its imaging arm, the LA5c study, was released on OpenfMRI in 2016 and now lives on OpenNeuro as ds000030 under a CC0 waiver. It is a common benchmark for transdiagnostic psychiatry, fMRI preprocessing pipelines and MRI quality control.

Composition

The current snapshot (1.0.0, April 2020) holds 272 participants aged 21 to 50: 130 healthy controls, 50 people with schizophrenia, 49 with bipolar disorder and 43 with adult ADHD. Each person was scanned in two one-hour sessions. One session included an MPRAGE T1-weighted scan, 64-direction diffusion imaging, a balloon analog risk task and a paired-associate memory task; the other included resting-state fMRI, breath holding, stop-signal, spatial working memory and task-switching runs. Not every participant completed every scan; the participants table flags which ones are present. Extensive neuropsychological test results are in the phenotype folder.

Acquisition

All data come from two 3T Siemens Trio scanners at UCLA (Ahmanson-Lovelace Brain Mapping Center and Staglin Center). Functional runs used a 2 s TR echo-planar sequence with 4 mm slices. A matched-bandwidth T2-weighted scan was collected but is not part of the release. Anatomical images were defaced with mri_deface before sharing, and the data are organized in BIDS.

Annotations

Diagnoses were made with the SCID for DSM-IV and an adult ADHD interview. There are no image annotations. The release includes MRIQC quality metrics, diffusion quality ratings and a flag for a ghosting artifact; FreeSurfer and fMRIPrep derivatives were published separately (Gorgolewski et al. 2017).

Known limitations

  • Inclusion was restricted by ethnicity (White non-Hispanic, or Hispanic/Latino) and to right-handed adults.
  • The OpenNeuro description text gives older group sizes (138, 58, 49, 45) than the participants table and paper.
  • The diffusion data of many subjects are affected by a vibration artifact of the Trio scanners of that era.
  • Patients could stay on stable medication, which confounds group comparisons.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 272 subjects.

Sex

  • Female 117 43%
  • Male 155 57%

Age

mean 33.2± 9.4 · range 21 to 50
0
50
100
123
20-2930-3940-4950-59

Age by sex

Reported cross table. Missing cells were not published (fewer than 10 subjects or not reported).

Female Male
  • 31
    40-49
    49
  • 27
    30-39
    35
  • 55
    20-29
    68

Contrast combinations

How many subjects have exactly each set of contrasts.

T1wdwiboldSubjects with exactly this set
262
7
3

Contrast / sequence

subjects, values can overlap

  • BOLD fMRI 272 100%
  • T1-weighted 265 97%
  • Diffusion-weighted 262 96%

Condition

subjects, values can overlap

  • Healthy control 130 48%
  • Schizophrenia 50 18%
  • Bipolar disorder 49 18%
  • ADHD 43 16%

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
Open download

Download without an account

Access page

Creative Commons Zero 1.0 Universal

Public domain dedication. Do anything with the data, including commercial use, without asking and without having to give credit.

dataset_description.json of snapshot 1.0.0 states "License" CC0.

Original license text Version read: 1.0 Checked 2026-10-07

What you can do

  • Yes
  • Yes
  • Yes
  • Yes

What you can share

  • Yes
  • Yes
  • Yes

What you must do

  • No
  • Share alike No
  • No
  • No
  • Manuscript review No
  • Release code No
  • Return results No
  • Delete after use No

Limits

  • No
  • Location limits No

Citation

Poldrack RA, et al. A phenome-wide examination of neural and cognitive function. Scientific Data 3, 160110 (2016). doi:10.1038/sdata.2016.110. For derived data also cite Gorgolewski KJ, et al. F1000Research 6:1262 (2017).

All numbers

Every number on this page, as stored in stats.csv, with its source.

MeasureBreakdownValueSource
Subjectstotal
272 rows; the OpenNeuro snapshot summary also lists 272 subjects
272ds000030-participants
Subjectscondition=healthy
diagnosis CONTROL; the paper also reports 130
130ds000030-participants
Subjectscondition=schizophrenia
diagnosis SCHZ; the paper also reports 50
50ds000030-participants
Subjectscondition=bipolar_disorder
diagnosis BIPOLAR; the paper also reports 49
49ds000030-participants
Subjectscondition=adhd
diagnosis ADHD; the paper also reports 43
43ds000030-participants
Subjectssex=female
gender F
117ds000030-participants
Subjectssex=male
gender M
155ds000030-participants
Subjectsage=20-29 123ds000030-participants
Subjectsage=30-39 62ds000030-participants
Subjectsage=40-49 80ds000030-participants
Subjectsage=50-59
all aged exactly 50
7ds000030-participants
Subjectscontrast=T1w
T1w column = 1
265ds000030-participants
Subjectscontrast=dwi
dwi column = 1
262ds000030-participants
Subjectscontrast=bold
at least one of the eight fMRI task/rest columns = 1
272ds000030-participants
Subjectscontrast_set=bold+dwi+T1w 262ds000030-participants
Subjectscontrast_set=bold+T1w 3ds000030-participants
Subjectscontrast_set=bold 7ds000030-participants
Subjectssex=female;age=20-29 55ds000030-participants
Subjectssex=male;age=20-29 68ds000030-participants
Subjectssex=female;age=30-39 27ds000030-participants
Subjectssex=male;age=30-39 35ds000030-participants
Subjectssex=female;age=40-49 31ds000030-participants
Subjectssex=male;age=40-49 49ds000030-participants
Subjectscondition=healthy;sex=female 62ds000030-participants
Subjectscondition=healthy;sex=male 68ds000030-participants
Subjectscondition=schizophrenia;sex=female 12ds000030-participants
Subjectscondition=schizophrenia;sex=male 38ds000030-participants
Subjectscondition=bipolar_disorder;sex=female 21ds000030-participants
Subjectscondition=bipolar_disorder;sex=male 28ds000030-participants
Subjectscondition=adhd;sex=female 22ds000030-participants
Subjectscondition=adhd;sex=male 21ds000030-participants
Subjectscondition=healthy;age=20-29 72ds000030-participants
Subjectscondition=healthy;age=30-39 27ds000030-participants
Subjectscondition=healthy;age=40-49 30ds000030-participants
Subjectscondition=schizophrenia;age=20-29 14ds000030-participants
Subjectscondition=schizophrenia;age=30-39 13ds000030-participants
Subjectscondition=schizophrenia;age=40-49 23ds000030-participants
Subjectscondition=bipolar_disorder;age=20-29 16ds000030-participants
Subjectscondition=bipolar_disorder;age=30-39 14ds000030-participants
Subjectscondition=bipolar_disorder;age=40-49 17ds000030-participants
Subjectscondition=adhd;age=20-29 21ds000030-participants
Subjectscondition=adhd;age=40-49 10ds000030-participants
Mean agetotal 33.2ds000030-participants
Age SDtotal 9.4ds000030-participants
Median agetotal 31ds000030-participants
Minimum agetotal 21ds000030-participants
Maximum agetotal 50ds000030-participants

Sources

The keys used in the table above.