Hyperactivity/Inattention in Autism, NYU (NDA 1551)

This NIMH Data Archive collection holds the imaging and clinical data of an NIH-funded study at New York University, led by F. Xavier Castellanos (grant R01HD065282), on the brain basis of hyperactivity and inattention in children with autism. The collection record describes a planned sample of about 100 children with autism spectrum disorder, 50 with ADHD and 50 typically developing children, imaged with MRI and assessed with diagnostic and behavioural instruments. Data were submitted until 2014.

Composition

The archive lists 210 subjects with shared data, of whom 135 have records in the image03 imaging structure. The clinical structures include the ADI-R (89 subjects), ADOS modules (mostly module 3, 105 subjects), Conners parent (200) and teacher (172) rating scales, a diagnosis form (203), the SRS (205), the SCQ (201), the Vineland-II (194) and the WASI (196). The public records do not break the subjects down by diagnostic group, sex or age, so only autism is listed as a confirmed condition here; the ADHD and typically developing groups are stated as planned in the collection description. In 2013, Supekar and colleagues found 15 children with autism aged 7 to 13 with resting-state fMRI in this collection and noted it then held no typically developing children, so they took matched controls from the NYU site of ADHD-200.

Acquisition

The collection contains structural and resting-state functional brain MRI. Secondary NDA studies derived cortical thickness from T1-weighted images of 117 subjects of this collection and resting-state connectivity from its fMRI. Scanner, sequence parameters, field strength and file formats are not given in the public records read for this entry.

Annotations

There are no image labels. Subjects carry diagnostic, cognitive and behavioural assessment records.

Known limitations

Group sizes, demographics and acquisition details are not public. Access requires an approved NIMH Data Archive request, and the data use terms of the archive apply.