B-SNIP 1
Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP 1)
Five-site US study of 933 probands with schizophrenia, schizoaffective disorder or psychotic bipolar I disorder, 1,055 first-degree relatives and 459 healthy controls, with 3T structural, diffusion and resting-state MRI, EEG, eye tracking and cognition, shared through the NIMH Data Archive.
Overview
B-SNIP 1 is a family study of psychosis run by a consortium of five US research groups. It recruited people with schizophrenia, schizoaffective disorder or bipolar I disorder with psychosis, their first-degree relatives and healthy controls, and phenotyped all of them with the same clinical, cognitive, neurophysiological and imaging protocol. Its aim was to test whether such biological measures follow the DSM-IV diagnoses or cut across them. Data are held in NIMH Data Archive collection 2274.
Composition
The clinical paper reports 933 clinically stable probands (397 schizophrenia, 224 schizoaffective disorder, 312 psychotic bipolar I disorder), 1,055 first-degree relatives (parents, siblings and children) and 459 healthy controls, recruited from 2008 until September 2012. Mean ages of the proband groups and controls lie between 35 and 37 years; relatives are older on average. Two thirds of the schizophrenia probands are male, against a minority in the other groups. Sites were in Baltimore, Chicago, Dallas, Detroit and Boston, and Hartford. The NDA collection lists 2,440 shared subjects, 1,098 of them with records in the shared image data structure.
Acquisition
Each participant was meant to receive structural, diffusion tensor and resting-state functional MRI, alongside resting and task EEG, eye movement tasks, the Brief Assessment of Cognition in Schizophrenia and a blood sample for genetics. Structural scans were 3D T1-weighted MP-RAGE images following the ADNI protocol, acquired on 3T GE Signa, Philips Achieva, Siemens Allegra and Siemens Trio systems, with every participant at a site scanned on the same magnet.
Annotations
There are no image labels. Each subject carries a consensus DSM-IV diagnosis from structured interviews, symptom and functioning ratings (PANSS, Young Mania Rating Scale, MADRS, Birchwood Social Functioning Scale), personality ratings for relatives and family history.
Known limitations
The sample is a research sample recruited by advertising, not a clinical or epidemiological one. Not every subject has imaging, and the per-sequence counts of shared scans are not published. Scanners differ between sites. Diagnostic and sex counts in the paper describe the recruitment as of September 2012 and do not exactly match the shared NDA release.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 2,447 subjects.
Sex
- Male 1,025 100%
Covers 1,025 of 2,447 subjects.
Modality
subjects
- MRI 1,098 45%
Condition
subjects, values can overlap
- Psychotic disorder 933 38%
- Healthy control 459 19%
- Schizophrenia 397 16%
- Bipolar disorder 312 13%
- Schizoaffective disorder 224 9%
Country
subjects
- United States 2,447 100%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
A research proposal is reviewed and approved
NIMH Data Archive Data Use Terms and Conditions (Data Use Certification)
Terms every NIMH Data Archive data access request accepts. Data are for research, scholarship or teaching; they may only be shared with collaborators who hold their own access; re-identification is forbidden; each publication needs an NDA Study linked to the data and an acknowledgement; downloaded data must be deleted when the research ends or after the one-year access period.
B-SNIP 1 is NIMH Data Archive collection 2274. Access needs an approved NDA data access request; study-specific clauses of the permission group are not broken down here.
What you can do
- Not stated
- Not stated
- Conditional
- Conditional
What you can share
- No
- Conditional
- Share trained models Not stated
What you must do
- Yes
- Share alike No
- Yes
- Conditional
- Manuscript review No
- No
- Yes
- Yes
Limits
- Yes
- Location limits No
Citation
Tamminga CA, Ivleva EI, Keshavan MS, Pearlson GD, Clementz BA, Witte B, Morris DW, Bishop J, Thaker GK, Sweeney JA. Clinical Phenotypes of Psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP). Am J Psychiatry 170(11):1263-1274 (2013). doi:10.1176/appi.ajp.2013.12101339
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total sum of 933 probands, 1055 first-degree relatives and 459 healthy controls recruited through September 2012; the NDA collection lists 2440 shared subjects | 2,447 | tamminga2013 Results |
| Subjects | sex=male sum of male counts over the seven groups; sex missing for some subjects | 1,025 | tamminga2013 Table 1 |
| Subjects | condition=psychotic_disorder probands only | 933 | tamminga2013 Results |
| Subjects | condition=schizophrenia probands only | 397 | tamminga2013 Table 1 |
| Subjects | condition=schizoaffective_disorder probands only; 153 bipolar type and 71 depressed type | 224 | tamminga2013 Table 1 |
| Subjects | condition=bipolar_disorder probands with psychotic bipolar I disorder | 312 | tamminga2013 Table 1 |
| Subjects | condition=healthy | 459 | tamminga2013 Table 1 |
| Subjects | condition=schizophrenia;sex=male probands only | 267 | tamminga2013 Table 1 |
| Subjects | condition=schizoaffective_disorder;sex=male probands only | 93 | tamminga2013 Table 1 |
| Subjects | condition=bipolar_disorder;sex=male probands only | 110 | tamminga2013 Table 1 |
| Subjects | condition=healthy;sex=male | 210 | tamminga2013 Table 1 |
| Subjects | country=US five US sites | 2,447 | tamminga2013 Method |
| Subjects | modality=MR subjects in the shared NDA Image data structure | 1,098 | nda-collection-2274 Shared Data |
| Mean age | condition=schizophrenia probands | 35.7 | tamminga2013 Table 1 |
| Mean age | condition=schizoaffective_disorder probands | 36.6 | tamminga2013 Table 1 |
| Mean age | condition=bipolar_disorder probands | 36.4 | tamminga2013 Table 1 |
| Mean age | condition=healthy | 36.5 | tamminga2013 Table 1 |
Sources
The keys used in the table above.
- tamminga2013 Tamminga et al. 2013, Clinical Phenotypes of Psychosis in B-SNIP, Am J Psychiatry (author manuscript PMC12866513) paper
- ivleva2013 Ivleva et al. 2013, Gray Matter Volume as an Intermediate Phenotype for Psychosis (B-SNIP), Am J Psychiatry (PMC6487663) paper
- nda-collection-2274 NIMH Data Archive collection 2274 page (B-SNIP 1), General and Shared Data tabs website