B-SNIP 1
Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP 1)
Brain MRI, EEG, eye tracking and cognition from people with schizophrenia, schizoaffective disorder or psychotic bipolar disorder, their relatives and healthy controls, collected to test whether biological measures follow diagnoses or cut across them. 933 patients, 1,055 relatives and 459 controls.
Overview
B-SNIP 1 is a family study of psychosis run by a consortium of five US research groups. It recruited people with schizophrenia, schizoaffective disorder or bipolar I disorder with psychosis, their first-degree relatives and healthy controls, and phenotyped all of them with the same clinical, cognitive, neurophysiological and imaging protocol. Its aim was to test whether such biological measures follow the DSM-IV diagnoses or cut across them. Data are held in NIMH Data Archive collection 2274.
Composition
The clinical paper reports 933 clinically stable probands (397 schizophrenia, 224 schizoaffective disorder, 312 psychotic bipolar I disorder), 1,055 first-degree relatives (parents, siblings and children) and 459 healthy controls, recruited from 2008 until September 2012. Mean ages of the proband groups and controls lie between 35 and 37 years; relatives are older on average. Two thirds of the schizophrenia probands are male, against a minority in the other groups. Sites were in Baltimore, Chicago, Dallas, Detroit and Boston, and Hartford. The NDA collection lists 2,440 shared subjects, 1,098 of them with records in the shared image data structure.
Acquisition
Each participant was meant to receive structural, diffusion tensor and resting-state functional MRI, alongside resting and task EEG, eye movement tasks, the Brief Assessment of Cognition in Schizophrenia and a blood sample for genetics. Structural scans were 3D T1-weighted MP-RAGE images following the ADNI protocol, acquired on 3T GE Signa, Philips Achieva, Siemens Allegra and Siemens Trio systems, with every participant at a site scanned on the same magnet.
Annotations
There are no image labels. Each subject carries a consensus DSM-IV diagnosis from structured interviews, symptom and functioning ratings (PANSS, Young Mania Rating Scale, MADRS, Birchwood Social Functioning Scale), personality ratings for relatives and family history.
Known limitations
The sample is a research sample recruited by advertising, not a clinical or epidemiological one. Not every subject has imaging, and the per-sequence counts of shared scans are not published. Scanners differ between sites. Diagnostic and sex counts in the paper describe the recruitment as of September 2012 and do not exactly match the shared NDA release.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 2,447 subjects.
Sex
- Male 1,025 100%
Covers 1,025 of 2,447 subjects.
Condition
Groups can overlap
- Psychotic disorder 933 38%
- Healthy control 459 19%Age mean 36.5
- Schizophrenia 397 16%Age mean 35.7
- Bipolar disorder 312 13%Age mean 36.4
- Schizoaffective disorder 224 9%Age mean 36.6
Results, Table 1 in Tamminga et al. 2013, Clinical Phenotypes of Psychosis in B-SNIP, Am J Psychiatry (author manuscript PMC12866513)
Modality
- MRI 1,098 45%
Shared Data in NIMH Data Archive collection 2274 page (B-SNIP 1), General and Shared Data tabs
Country
- United States 2,447 100%
Condition by sex
Reported cross table. A dot marks a cell the source does not give.
| Male | |
|---|---|
| Schizophrenia | 267 |
| Healthy control | 210 |
| Bipolar disorder | 110 |
| Schizoaffective disorder | 93 |
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
A research proposal is reviewed and approved
NIMH Data Archive Data Use Terms and Conditions (Data Use Certification)
Terms every NIMH Data Archive data access request accepts. Data are for research, scholarship or teaching; they may only be shared with collaborators who hold their own access; re-identification is forbidden; each publication needs an NDA Study linked to the data and an acknowledgement; downloaded data must be deleted when the research ends or after the one-year access period.
B-SNIP 1 is NIMH Data Archive collection 2274. Access needs an approved NDA data access request; study-specific clauses of the permission group are not broken down here.
What you can do
- Not stated
- Not stated
- Not stated
- Conditional
- Conditional
What you can share
- No
- Conditional
- Share trained models Not stated
What you must do
- Yes
- Share alike No
- Yes
- Conditional
- Manuscript review No
- No
- Yes
- Yes
Limits
- Yes
- Location limits No
Citation
Tamminga CA, Ivleva EI, Keshavan MS, Pearlson GD, Clementz BA, Witte B, Morris DW, Bishop J, Thaker GK, Sweeney JA. Clinical Phenotypes of Psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP). Am J Psychiatry 170(11):1263-1274 (2013). doi:10.1176/appi.ajp.2013.12101339
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.
- Tamminga et al. 2013, Clinical Phenotypes of Psychosis in B-SNIP, Am J Psychiatry (author manuscript PMC12866513) paper
- Ivleva et al. 2013, Gray Matter Volume as an Intermediate Phenotype for Psychosis (B-SNIP), Am J Psychiatry (PMC6487663) paper
- NIMH Data Archive collection 2274 page (B-SNIP 1), General and Shared Data tabs website