VITA Vienna Transdanube Aging study
Vienna Transdanube Aging "VITA" study
Population-based birth cohort of 75-year-olds from two districts of Vienna, examined from 2000 with 1.0 T brain MRI (T1w MPRAGE, T2w, PDw), cognitive testing and blood markers, and followed every 30 months to study incident dementia. Scans are not public.
Overview
The Vienna Transdanube Aging study (VITA) is a prospective cohort of people born between May 1925 and June 1926 who lived in the 21st and 22nd districts of Vienna, on the east bank of the Danube. Run by the Ludwig Boltzmann Institute of Aging Research and the Danube Hospital, it asks which measures at age 75 predict later dementia. The design paper names eight candidate predictors, two of them from MRI: hippocampal atrophy and atrophy of the substantia innominata. Participants had a day-long examination with interviews, neuropsychological tests, psychiatric and neurological scales, blood and genetic markers, and a cranial MRI, and were invited back every 30 months. The scans have not been released publicly; one VITA paper offers its analysis data on reasonable request to the authors.
Composition
About 1,745 residents of the target age were invited, and between 36.7% and 44.3% took part. A baseline brain MRI was obtained for 532 participants aged 75 between May 2000 and November 2002, of whom 318 were women. Later papers report slightly different baseline numbers (for example 503 with complete neurological work-up including MRI), so the exact size of the imaging set depends on the analysis. Follow-up visits at 30 and 60 months repeated the MRI. A subsample that died at the Danube Hospital also had brain autopsies, and 68 of them had both MRI and neuropathology.
Acquisition
For the autopsy subsample the documented protocol was a 1.0 T Siemens Impact Expert with a circularly polarized head coil: coronal 3D T1-weighted MPRAGE at 1 mm, a T2-weighted turbo spin echo, a transverse proton density series and a thin inversion recovery series of the olfactory region.
Annotations
The released papers describe radiological ratings rather than voxel labels: medial temporal lobe atrophy, white matter lesion and lacune grades, Evans index, incidental meningiomas (9 at baseline, all in women) and FreeSurfer regional measures. Clinical labels include mild cognitive impairment and dementia diagnoses by NINCDS-ADRDA criteria at follow-up, and NIA-AA neuropathology scores for the autopsy subsample.
Known limitations
- No public release, no website and no published data use terms; access depends on the investigators.
- A single birth year from one urban area of Austria, so age has almost no variance.
- Low field strength (1.0 T).
- The scan protocol is only documented in detail for the autopsy subsample.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 532 subjects.
Sex
- Female 318 100%
Covers 318 of 532 subjects.
Age
Contrast / sequence
subjects, values can overlap
- T1-weighted 68 13%
- T2-weighted 68 13%
- Proton density weighted 68 13%
Condition
subjects, values can overlap
- Meningioma 9 2%
Scanner vendor
subjects
- Siemens Healthineers 68 13%
Field strength
subjects
- 1 T 68 13%
Country
subjects
- Austria 532 100%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Ask the authors or the data holder. No published process or terms, and access is at their discretion
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
No study website, license or data use terms were found. The 2018 VITA MRI paper states that the datasets analyzed in it are available from the corresponding author on reasonable request; no wider sharing route is published. The CC BY license of that article covers the text only.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Fischer P, Jungwirth S, Krampla W, Weissgram S, Kirchmeyr W, Schreiber W, Huber K, Rainer M, Bauer P, Tragl KH. Vienna Transdanube Aging "VITA": study design, recruitment strategies and level of participation. Journal of Neural Transmission Supplementum (62), 105-116 (2002). doi:10.1007/978-3-7091-6139-5_11
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total 75-year-olds scanned at baseline between May 2000 and November 2002 | 532 | krampla2004 Abstract |
| Subjects | sex=female | 318 | krampla2004 Abstract |
| Subjects | age=70-79 all participants aged 75 at baseline | 532 | krampla2004 Abstract |
| Subjects | country=AT residents of a defined area of Vienna | 532 | krampla2004 Abstract |
| Subjects | condition=meningioma clinically silent meningiomas found on baseline MRI; all in women | 9 | krampla2004 Abstract |
| Subjects | field_strength=1 baseline MRI of the subsample with neuropathology; protocol for the full cohort not stated in this source | 68 | kautzky2018 Materials and Methods |
| Subjects | vendor=siemens Siemens Impact Expert; neuropathology subsample | 68 | kautzky2018 Materials and Methods |
| Subjects | contrast=T1w coronal 3D MPRAGE 1 mm; neuropathology subsample | 68 | kautzky2018 Materials and Methods |
| Subjects | contrast=T2w turbo spin echo; neuropathology subsample | 68 | kautzky2018 Materials and Methods |
| Subjects | contrast=PDw transverse proton density; neuropathology subsample | 68 | kautzky2018 Materials and Methods |
Sources
The keys used in the table above.
- fischer2002 Fischer et al. 2002, Journal of Neural Transmission Supplementum 62 (study design) paper
- krampla2004 Krampla et al. 2004, Cancer 100(6) (meningioma frequency at age 75) paper
- akiguchi2014 Akiguchi et al. 2014, Annals of Clinical and Translational Neurology 1(8) (DESH-iNPH) paper
- kautzky2018 Kautzky et al. 2018, Frontiers in Aging Neuroscience 10:406 (MRI prediction of AD neuropathology) paper