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Open Imaging Index
CT PET Brain

Refractory epilepsy FDG PET/CT (Unicamp)

Interictal and postictal 18F-FDG PET/CT in epileptogenic zone localization

Brain FDG PET/CT of surgical candidates with drug-refractory focal epilepsy at a university hospital in Campinas, Brazil, acquired under EEG monitoring to compare postictal with interictal localization of the epileptogenic zone. 110 patients. Images not shared.

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Overview

This cohort comes from the State University of Campinas (Unicamp) in Brazil. Patients with focal epilepsy that did not respond to drug treatment were enrolled prospectively between January 2015 and July 2017 and had brain FDG PET/CT while EEG was recorded around the tracer injection. Because some patients had a seizure shortly before injection, the study could compare how often postictal and interictal scans agreed with the reference location of the epileptogenic zone. The images are not shared: the paper has no data availability statement, and the SciELO figshare record attached to it contains only the article figures.

Composition

151 patients were scanned and 110 remained after excluding those whose epileptogenic zone could not be pinned down. The sample has 67 women and 43 men, aged 3 to 63 at inclusion (mean 35.0). Table 1 classes 64 patients as temporal and 46 as extratemporal lobe epilepsy. Ten patients had a single seizure in the hour before injection (postictal group), and 100 had none (interictal group). 24 patients went on to surgery; histopathology showed hippocampal sclerosis, cortical dysplasia, gliosis and single cases of oligodendroglial hyperplasia and glioma.

Acquisition

Patients rested for 90 minutes in a dimly lit EEG room, received 185 MBq of FDG, and were scanned 60 minutes later on a Siemens Biograph 40 TruePoint mCT with one 5-minute bed position over the head. CT served for attenuation correction and anatomy. EEG ran from 60 minutes before to 30 minutes after injection.

Annotations

Two nuclear medicine physicians read each scan independently and settled disagreements by consensus, marking hypo- or hypermetabolic areas as the presumed epileptogenic zone. The reference standard was histopathology with follow-up after surgery, or a multidisciplinary consensus based on EEG, video EEG, MRI and other tests.

Known limitations

  • Images, reads and clinical data are not released.
  • Single centre and single scanner.
  • Only ten scans are postictal.
  • Most reference locations rest on expert consensus rather than surgery.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 110 subjects.

Sex

  • Female 67 61%
  • Male 43 39%

Table 1 in Carvalho et al. 2022, Radiologia Brasileira 55(5), 273-279

PET tracer

  • [18F]FDG 110 100%

Materials and Methods (Patient preparation and image acquisition) in Carvalho et al. 2022, Radiologia Brasileira 55(5), 273-279

Condition

Groups can overlap

  • Epilepsy 110 100%
  • Temporal lobe epilepsy 64 58%

Table 1 in Carvalho et al. 2022, Radiologia Brasileira 55(5), 273-279

Age

mean 35 ± 15, median 36, range 3 to 63

No age bins reported.

Table 1 in Carvalho et al. 2022, Radiologia Brasileira 55(5), 273-279

Modality

  • PET 110 100%
  • CT 110 100%

Materials and Methods (Patient preparation and image acquisition) in Carvalho et al. 2022, Radiologia Brasileira 55(5), 273-279

Scanner vendor

  • Siemens Healthineers 110 100%

Materials and Methods (Patient preparation and image acquisition) in Carvalho et al. 2022, Radiologia Brasileira 55(5), 273-279

Country

  • Brazil 110 100%

Affiliations; Materials and Methods in Carvalho et al. 2022, Radiologia Brasileira 55(5), 273-279

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
Not shared

The data are not available outside the institution or study that holds them

The paper has no data availability statement. Its figshare record (SciELO) holds only the article's figures, no patient images.

Access page

No published license or data use terms

The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.

No license or data use terms for the images are published. The CC BY 4.0 label of the figshare record covers the article figures only.

Original license text Checked 2026-10-08

What you can do

  • Commercial use Not stated
  • Not stated
  • Train ML models Not stated
  • Create derived data Not stated
  • Publish results Not stated

What you can share

  • Share the data Not stated
  • Share derived data Not stated
  • Share trained models Not stated

What you must do

  • Cite or credit Not stated
  • Share alike Not stated
  • Sign an agreement Not stated
  • Ethics approval Not stated
  • Manuscript review Not stated
  • Release code Not stated
  • Return results Not stated
  • Delete after use Not stated

Limits

  • No re-identification Not stated
  • Location limits Not stated

Citation

Carvalho MS, Alvim MKM, Etchebehere E, et al. Interictal and postictal 18F-FDG PET/CT in epileptogenic zone localization. Radiologia Brasileira 55(5), 273-279 (2022). doi:10.1590/0100-3984.2021.0141

Sources

Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.