STRIvE eating disorders MRI
STRIvE-ED stress and eating disorders inpatient MRI study (University of Cambridge)
Brain MRI, task fMRI and spectroscopy of women with binge-eating disorders and controls under acute stress, collected to study how stress affects self-control. 85 women from Cambridge, UK, with anorexia (binge/purge type), bulimia or no disorder. Images are not shared.
Overview
STRIvE-ED is a University of Cambridge study of how acute psychological stress affects self-control in women with binge-eating disorders. Women with anorexia nervosa of the binge-eating/purging subtype, women with bulimia nervosa and healthy women stayed two days in an inpatient research facility, where they had repeated brain MRI, blood sampling for stress and gut hormones, and a free-choice meal after each scan. The images have not been released. The study name appears in the authors' public stimulus code repository.
Composition
After outpatient screening of 100 volunteers, 85 women took part: 22 with anorexia nervosa (binge/purge subtype), 33 with bulimia nervosa and 30 controls. Eligible women were 18 to 40 years old, right-handed and had a BMI up to 29.9; the mean age was 24.0 years. Diagnoses followed DSM-5, set by structured clinical interview. Groups were matched on age and IQ, and the bulimia and control groups also on BMI. Most patients had comorbid psychiatric diagnoses and many took psychotropic medication. Recruitment ran through advertisements, an eating disorders charity and an adult NHS eating disorder service in Cambridgeshire.
Acquisition
All scans were made on one 3T Siemens SkyraFit at the Wolfson Brain Imaging Centre, Addenbrooke's Hospital, with a 32-channel head coil. Each day included a 1 mm isotropic T1-weighted scan and two task fMRI runs of a stop-signal anticipation task (3 mm voxels, TR 1.6 s, 631 volumes), one before and one after either a stress induction or a control arithmetic task, in counterbalanced order. On the control day, single-voxel proton spectroscopy was acquired in the right inferior lateral prefrontal and medial occipital cortex.
Annotations
No image annotations. Labels are diagnosis, clinical scales, task performance, hormone levels and food intake.
Known limitations
- Not shared. Neither paper has a data availability statement, and no access process or terms are published.
- Run counts vary: fMRI runs were lost to head motion and technical errors, and one participant was excluded for an incidental white matter finding.
- Women only, from a single site and scanner.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 85 subjects.
Sex
- Female 85 100%
Materials and Methods: Participants in Westwater et al. 2021, Journal of Neuroscience (PMC8152613)
Contrast / sequence
Groups can overlap
- BOLD fMRI 84 99%
Materials and Methods: Data analysis—fMRI in Westwater et al. 2021, Journal of Neuroscience (PMC8152613)
Scanner vendor
- Siemens Healthineers 85 100%
Materials and Methods: Image acquisition in Westwater et al. 2021, Journal of Neuroscience (PMC8152613)
Field strength
- 3 T 85 100%
Materials and Methods: Image acquisition in Westwater et al. 2021, Journal of Neuroscience (PMC8152613)
Age
mean 24 ± 4
No age bins reported.
Materials and Methods: Participants in Westwater et al. 2021, Journal of Neuroscience (PMC8152613)
Modality
- MRI 85 100%
Materials and Methods: Study design in Westwater et al. 2021, Journal of Neuroscience (PMC8152613)
Condition
Groups can overlap
- Eating disorder 55 65%
- Healthy control 30 35%Age mean 23.9
Table 1 in Westwater et al. 2021, Journal of Neuroscience (PMC8152613)
Country
- United Kingdom 85 100%
Materials and Methods: Participants in Westwater et al. 2021, Journal of Neuroscience (PMC8152613)
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
The data are not available outside the institution or study that holds them
Neither Westwater et al. (2021, J Neurosci) nor Westwater et al. (2022, Translational Psychiatry) has a data availability statement, and no download or request procedure for the images was found. The public GitHub repository mwestwater/STRIvE-ED holds only the stimulus code of the stress and control tasks.
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
No license or data use terms are published for the images.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Westwater ML, Mancini F, Gorka AX, Shapleske J, Serfontein J, Grillon C, Ernst M, Ziauddeen H, Fletcher PC. Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa. J Neurosci 41(20):4487-4499 (2021). doi:10.1523/JNEUROSCI.2853-20.2021
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.