STRIvE eating disorders MRI
STRIvE-ED stress and eating disorders inpatient MRI study (University of Cambridge)
3T brain MRI (T1-weighted, task fMRI, 1H-MRS) of 85 women from Cambridge, UK: 22 with anorexia nervosa (binge/purge subtype), 33 with bulimia nervosa and 30 controls, scanned on two days under acute stress and a control task. Images are not shared.
Overview
STRIvE-ED is a University of Cambridge study of how acute psychological stress affects self-control in women with binge-eating disorders. Women with anorexia nervosa of the binge-eating/purging subtype, women with bulimia nervosa and healthy women stayed two days in an inpatient research facility, where they had repeated brain MRI, blood sampling for stress and gut hormones, and a free-choice meal after each scan. The images have not been released. The study name appears in the authors' public stimulus code repository.
Composition
After outpatient screening of 100 volunteers, 85 women took part: 22 with anorexia nervosa (binge/purge subtype), 33 with bulimia nervosa and 30 controls. Eligible women were 18 to 40 years old, right-handed and had a BMI up to 29.9; the mean age was 24.0 years. Diagnoses followed DSM-5, set by structured clinical interview. Groups were matched on age and IQ, and the bulimia and control groups also on BMI. Most patients had comorbid psychiatric diagnoses and many took psychotropic medication. Recruitment ran through advertisements, an eating disorders charity and an adult NHS eating disorder service in Cambridgeshire.
Acquisition
All scans were made on one 3T Siemens SkyraFit at the Wolfson Brain Imaging Centre, Addenbrooke's Hospital, with a 32-channel head coil. Each day included a 1 mm isotropic T1-weighted scan and two task fMRI runs of a stop-signal anticipation task (3 mm voxels, TR 1.6 s, 631 volumes), one before and one after either a stress induction or a control arithmetic task, in counterbalanced order. On the control day, single-voxel proton spectroscopy was acquired in the right inferior lateral prefrontal and medial occipital cortex.
Annotations
No image annotations. Labels are diagnosis, clinical scales, task performance, hormone levels and food intake.
Known limitations
- Not shared. Neither paper has a data availability statement, and no access process or terms are published.
- Run counts vary: fMRI runs were lost to head motion and technical errors, and one participant was excluded for an incidental white matter finding.
- Women only, from a single site and scanner.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 85 subjects.
Sex
- Female 85 100%
Age
mean 23.96± 3.98No age bins reported.
Modality
subjects
- MRI 85 100%
Contrast / sequence
subjects, values can overlap
- BOLD fMRI 84 99%
Condition
subjects, values can overlap
- Eating disorder 55 65%
- Healthy control 30 35%
Scanner vendor
subjects
- Siemens Healthineers 85 100%
Field strength
subjects
- 3 T 85 100%
Country
subjects
- United Kingdom 85 100%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
The data are not available outside the institution or study that holds them
Neither Westwater et al. (2021, J Neurosci) nor Westwater et al. (2022, Translational Psychiatry) has a data availability statement, and no download or request procedure for the images was found. The public GitHub repository mwestwater/STRIvE-ED holds only the stimulus code of the stress and control tasks.
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
No license or data use terms are published for the images.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Westwater ML, Mancini F, Gorka AX, Shapleske J, Serfontein J, Grillon C, Ernst M, Ziauddeen H, Fletcher PC. Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa. J Neurosci 41(20):4487-4499 (2021). doi:10.1523/JNEUROSCI.2853-20.2021
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total women eligible for the two-day inpatient session; 100 volunteers completed outpatient screening (Study design) | 85 | westwater2021 Materials and Methods: Participants |
| Subjects | modality=MR | 85 | westwater2021 Materials and Methods: Study design |
| Subjects | contrast=bold prestress run available from 84; poststress 79, preneutral 80, postneutral 81 | 84 | westwater2021 Materials and Methods: Data analysis—fMRI |
| Subjects | condition=eating_disorder 22 anorexia nervosa binge-eating/purging subtype plus 33 bulimia nervosa; sum of disjoint groups | 55 | westwater2021 Table 1 |
| Subjects | condition=healthy | 30 | westwater2021 Table 1 |
| Subjects | sex=female | 85 | westwater2021 Materials and Methods: Participants |
| Subjects | field_strength=3 Siemens SkyraFit | 85 | westwater2021 Materials and Methods: Image acquisition |
| Subjects | vendor=siemens | 85 | westwater2021 Materials and Methods: Image acquisition |
| Subjects | country=GB | 85 | westwater2021 Materials and Methods: Participants |
| Mean age | total | 24 | westwater2021 Materials and Methods: Participants |
| Age SD | total | 4 | westwater2021 Materials and Methods: Participants |
| Mean age | condition=healthy | 23.9 | westwater2021 Table 1 |
Sources
The keys used in the table above.
- westwater2021 Westwater et al. 2021, Journal of Neuroscience (PMC8152613) paper
- westwater2022 Westwater et al. 2022, Translational Psychiatry (PMC8924163) paper