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MRI Brain

SRPBS Multi-disorder MRI

SRPBS Multi-disorder MRI Dataset (DecNef Project Brain Data Repository)

Resting-state fMRI and structural brain MRI of healthy people and patients with autism, depression, schizophrenia, chronic pain and other conditions, built to train and test connectivity classifiers across sites. 1,627 Japanese participants from 12 sites, 1,410 released after registration.

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Overview

The SRPBS Multi-disorder MRI Dataset is the imaging release of the DecNef consortium, a group of Japanese universities and institutes formed in 2013 under the Strategic Research Program for the Promotion of Brain Science (SRPBS) and funded by AMED. It was built to train and test functional-connectivity classifiers for psychiatric disorders across sites. Data are hosted on Synapse and on the DecNef Project Brain Data Repository run by ATR.

Composition

The restricted release holds 1,627 participants (958 men, 669 women, mean age 38.2 years): 950 healthy controls, 255 with major depressive disorder, 147 with schizophrenia spectrum disorders, 125 with autism spectrum disorder, 67 with chronic pain, 41 with bipolar disorder, 10 with stroke, 4 with dysthymia and 28 with other diagnoses. The unrestricted release is the subset of 1,410 participants who consented to public release. Each participant has one resting-state fMRI run, one T1w scan and an optional B0 field map, together with age, sex, handedness, diagnosis and clinical rating scales, MRIQC metrics and a defacing quality rating.

Acquisition

All scans were done at 3T on Siemens (TimTrio, Trio, Verio, Spectra) and GE (Signa HDxt, MR750w) scanners at 12 sites in Japan. A shared protocol recommended a 10-minute eyes-open run of 240 volumes with TR 2.5 s and 3.3 mm in-plane resolution, but several sites used shorter runs or other parameters. T1w scans follow the J-ADNI2 protocol at about 1 mm isotropic. Faces were masked with SPM8 and mri_deface.

Annotations

Diagnoses were made by clinicians at each site with DSM-IV, DSM-IV-TR or DSM-5 criteria, supported by the MINI or SCID, and chronic pain by the IASP definition. Three raters scored the defacing of every T1w scan.

Known limitations

  • Diagnoses are not balanced across sites, so disorder and site are confounded. A separate Traveling Subject dataset of 9 men scanned at the sites is offered for harmonization.
  • Run length, TR and phase-encoding direction differ between sites.
  • The summary row of Table 3 in the descriptor gives a wrong sex split for autism; the site rows sum to 109 men and 16 women.
  • The two releases carry different terms, and the full release needs an approved application.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 1,627 subjects.

Sex

  • Female 669 41%
  • Male 958 59%

Table 3 in Tanaka et al. 2021, Scientific Data

Condition

Groups can overlap

  • Healthy control 950 58%
  • Major depressive disorder 255 16%
  • Schizophrenia 147 9%
  • Autism spectrum disorder 125 8%
  • Chronic pain 67 4%
  • Bipolar disorder 41 3%
  • Stroke 10 <1%
  • Dysthymic disorder 4 <1%

Table 3 in Tanaka et al. 2021, Scientific Data

Country

  • Japan 1,627 100%

Table 3 in Tanaka et al. 2021, Scientific Data

Age

mean 38.2 ± 14.8

No age bins reported.

Table 3 in Tanaka et al. 2021, Scientific Data

Contrast / sequence

Groups can overlap

  • BOLD fMRI 1,627 100%
  • T1-weighted 1,627 100%

Table 9 in Tanaka et al. 2021, Scientific Data

Scanner vendor

  • Siemens Healthineers 1,087 67%
  • GE HealthCare 540 33%

Tables 3 and 5 in Tanaka et al. 2021, Scientific Data

Field strength

  • 3 T 1,627 100%

From SRPBS Multidisorder MRI Dataset (restricted) page, DecNef Project Brain Data Repository

Condition by sex

Reported cross table. A dot marks a cell the source does not give.

FemaleMale
Healthy control411539
Major depressive disorder120135
Schizophrenia6186
Autism spectrum disorder16109
Chronic pain2839
Bipolar disorder1526
Stroke46
Dysthymic disorder13

Table 3 in Tanaka et al. 2021, Scientific Data

Contrast combinations

How many subjects have exactly each set of contrasts.

T1wboldSubjects with exactly this set
1,627

Table 9 in Tanaka et al. 2021, Scientific Data

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
Free registration

Create an account and accept terms online

Registration gives the unrestricted release of 1,410 participants. The full release of 1,627 participants needs a signed application approved by ATR (https://bicr-resource.atr.jp/srpbs1600/). Both are also on Synapse.

Access page

Different parts of the data carry different licenses. The summary on the right shows the most restrictive answer per rule.

For SRPBS Multi-disorder MRI Dataset (unrestricted), 1,410 participants who agreed to unrestricted release (Synapse syn22317081).

SRPBS Multi-disorder MRI Dataset (unrestricted) Terms of Use

Online registration on the DecNef Project Brain Data Repository or a Synapse account gives access. The data may not be used commercially and may not be copied or redistributed. Publications must acknowledge the DecNef Project Brain Data Repository, and co-researchers must register and accept the same terms.

Original license text Version read: Terms of use on the DecNef Project Brain Data Repository and Synapse (syn22317081) pages, read 2026-10-09 Checked 2026-10-09

What you can do

  • No
  • Not stated
  • Not stated
  • Not stated
  • Yes

What you can share

  • No
  • Not stated
  • Share trained models Not stated

What you must do

  • Yes
  • Share alike No
  • Yes
  • Ethics approval No
  • Manuscript review No
  • Release code No
  • Return results No
  • Delete after use No

Limits

  • Not stated
  • No

Commercial license: Not stated

For SRPBS Multi-disorder MRI Dataset (restricted), all 1,627 participants (Synapse syn22317079).

DecNef Project Consortium Application Form for Data Usage

Signed application approved by ATR, for principal investigators or researchers named by one. The data may not be redistributed, must be kept password protected and may be used for research, technology development and education. The repository page limits use to non-commercial purposes. ATR must be told about publications.

Original license text Version read: Application_Form_for_Data_Usage_DecNef_r1, read 2026-10-09 Checked 2026-10-09

What you can do

  • No
  • Not stated
  • Not stated
  • Not stated
  • Conditional

What you can share

  • No
  • Not stated
  • Share trained models Not stated

What you must do

  • Yes
  • Share alike No
  • Yes
  • Ethics approval No
  • No
  • Release code No
  • Return results No
  • Delete after use No

Limits

  • Not stated
  • No

Commercial license: Not stated

Citation

Tanaka SC, Yamashita A, Yahata N, et al. A multi-site, multi-disorder resting-state magnetic resonance image database. Scientific Data 8:227 (2021). doi:10.1038/s41597-021-01004-8

Sources

Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.