Cerebellum in Parkinson's disease FDG-PET (Rennes)

This entry describes the PET cohort behind a Neurology paper from the University of Rennes and Rennes University Hospital in France. The authors used resting-state FDG-PET of patients with Parkinson's disease to test whether cerebellar glucose metabolism tracks how impaired patients are in motor, cognitive and psychiatric domains, and which supratentorial regions co-vary with the cerebellar clusters they found. The images themselves are not public. The deposit on Dryad, mirrored on Zenodo under CC0, holds only the supplementary document of the paper.

Composition

The analysis included 90 patients with Parkinson's disease. The supplement compares them with 27 patients who were excluded, and reports a mean disease duration of 10.7 years (SD 4.4) in the included group. Each patient had clinical motor scales (UPDRS parts, Hoehn and Yahr, Schwab and England), a neuropsychological battery (Stroop, Trail Making, verbal fluency, Modified Card Sorting) and psychiatric ratings. These scores were reduced with principal component analysis per domain.

Acquisition

Each patient had one resting-state brain PET with [18F]FDG. The scanner, reconstruction and patient medication state during the scan are described in the paper, which could not be opened for this entry, so they are not listed here.

Annotations

There are no image annotations. The per-subject data are clinical scores and principal component values used as regressors against voxelwise cerebellar metabolism.

Known limitations

The images and the subject-level clinical table are not shared, and no request process or terms are published in the deposit. Counts here come from the abstract and the supplement; sex and age breakdowns are left out because they could not be read from an openly accessible source.