PING
Pediatric Imaging, Neurocognition, and Genetics (PING)
Cross-sectional multisite 3T MRI (T1w, T2w, diffusion, resting-state fMRI), NIH Toolbox cognition and genome-wide genotypes from 1,493 typically developing children and young people aged 3 to 21 at 10 US sites, shared through the NIMH Data Archive.
Overview
PING is a cross-sectional study of typically developing children, adolescents and young adults that pairs multimodal brain MRI with cognitive testing, developmental history and genome-wide genotyping. It was run by the Center for Human Development at UC San Diego with nine partner sites and funded by NIDA and NICHD, with the aim of linking genetic variation to brain structure, connectivity and cognition across development. Data collection is finished and the resource is now held in the NIMH Data Archive.
Composition
More than 1,700 participants were enrolled, and the shared repository keeps the 1,493 who have usable data for at least two data types (780 male). Of these, 1,239 have acceptable MRI (645 male), 1,453 have cognitive scores and 1,391 have genotypes. Ages range from 3 to 21 years. The NDA collection record lists 1,494 shared subjects. Children with neurological disorders, head trauma, preterm birth, autism spectrum disorder, bipolar disorder, schizophrenia or intellectual disability were excluded; learning disability and ADHD were not exclusion criteria.
Acquisition
Scanning took place at 10 US sites on 3T GE, Siemens and Philips systems with harmonized protocols. A standard session held a 3D T1-weighted scan and a 3D T2-weighted fast spin echo scan, both with prospective motion correction, a high angular resolution diffusion scan and a resting-state BOLD fMRI scan, the last two with built-in distortion correction. Cognition was measured with the NIH Toolbox Cognition Battery, and saliva DNA was genotyped on the Illumina Human660W-Quad BeadChip.
Annotations
There are no manual lesion or structure labels. The repository includes processed measures from a FreeSurfer-based pipeline (cortical thickness, surface area, subcortical volumes) and diffusion tensor measures for atlas-defined fiber tracts, plus genetic ancestry estimates. Raw scans were rated for quality by trained technicians.
Known limitations
The study is cross-sectional. Some site review boards did not allow full sharing, so part of the raw imaging and genetic data is restricted. Imaging is pooled from several scanner models and vendors, so scanner effects need modelling.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 1,493 subjects.
Sex
- Male 780 100%
Covers 780 of 1,493 subjects.
Modality
subjects
- MRI 1,239 83%
Condition
subjects, values can overlap
- Healthy control 1,493 100%
Field strength
subjects
- 3 T 1,239 83%
Country
subjects
- United States 1,493 100%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
A research proposal is reviewed and approved
NIMH Data Archive Data Use Terms and Conditions (Data Use Certification)
Terms every NIMH Data Archive data access request accepts. Data are for research, scholarship or teaching; they may only be shared with collaborators who hold their own access; re-identification is forbidden; each publication needs an NDA Study linked to the data and an acknowledgement; downloaded data must be deleted when the research ends or after the one-year access period.
The PING Data Resource is held in NIMH Data Archive collection 2607; the study page states that the data use policy and the Data Use Certification are managed by NDA. Access before the move to NDA ran under a separate PING Data Use Agreement, which is not broken down here.
What you can do
- Not stated
- Not stated
- Conditional
- Conditional
What you can share
- No
- Conditional
- Share trained models Not stated
What you must do
- Yes
- Share alike No
- Yes
- Conditional
- Manuscript review No
- No
- Yes
- Yes
Limits
- Yes
- Location limits No
Citation
Jernigan TL, Brown TT, Hagler DJ Jr, Akshoomoff N, Bartsch H, Newman E, et al. The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository. NeuroImage 124(Pt B):1149-1154 (2016). doi:10.1016/j.neuroimage.2015.04.057
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total participants with acceptable data for at least two data types; over 1700 were enrolled | 1,493 | jernigan2016 The PING Cohort |
| Subjects | sex=male | 780 | jernigan2016 The PING Cohort |
| Subjects | condition=healthy typically developing; neurological and several psychiatric disorders excluded | 1,493 | jernigan2016 The PING Cohort |
| Subjects | country=US 10 US sites | 1,493 | jernigan2016 Introduction |
| Subjects | modality=MR participants with acceptable imaging data | 1,239 | jernigan2016 The PING Cohort |
| Subjects | modality=MR;sex=male | 645 | jernigan2016 The PING Cohort |
| Subjects | field_strength=3 all scanners 3T | 1,239 | jernigan2016 Image Acquisition and Preprocessing |
| Minimum age | total "aged 3 to 21 years" | 3 | jernigan2016 Introduction |
| Maximum age | total some 20-year-olds turned 21 before data collection ended | 21 | jernigan2016 Introduction |
Sources
The keys used in the table above.
- jernigan2016 Jernigan et al. 2016, The PING Data Repository, NeuroImage (author manuscript PMC4628902) paper
- chd-ping UC San Diego Center for Human Development, PING Study page website
- nda-collection-2607 NIMH Data Archive collection 2607 record (Pediatric Imaging, Neurocognition, and Genetics) website