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Open Imaging Index
MRI Brain

GRACE Schizotypy Gut-Brain MRI (ds007694)

GRACE: A Multimodal Observational Case-Control Study Exploring Gut Microbiota-Hippocampus Alterations in Individuals With High Positive Schizotypy From the General Population

Brain MRI (T1-weighted, resting-state fMRI, arterial spin labeling) and hippocampal proton spectroscopy of young healthy adults with high or low positive schizotypy, collected to study links between gut microbiota and the hippocampus.

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Overview

This OpenNeuro release (ds007694) holds the brain imaging of GRACE, a cross-sectional case-control study from the University of Basel. The study asked whether young adults from the general population with strong positive schizotypy, meaning unusual perceptual experiences below the level of a psychiatric diagnosis, differ from people with very low schizotypy in their gut microbiota and in the structure, perfusion and chemistry of the hippocampus. The data are shared openly under CC0 in BIDS format. Gut microbiome sequencing, questionnaires and cognitive scores are not part of this release.

Composition

The paper enrolled 142 participants selected by screening 2,425 people with the short O-LIFE questionnaire; after one exclusion, 69 high and 72 low schizotypy participants formed the analysed sample. The release contains 139 subjects, 67 labelled high and 72 labelled low schizotypy in participants.tsv. Of these, 97 are female, 41 male and 1 recorded as other. Ages range from 18 to 25 years (mean 21.9). Each subject has one session. 136 have T1w, resting-state BOLD and ASL images, one lacks ASL, one has only ASL and spectroscopy, and one has spectroscopy only.

Acquisition

All imaging sidecars name a Siemens Prisma at 3 T, and the paper places every scan at University Hospital Basel. The session included an MPRAGE T1w image, a resting-state echo-planar BOLD run and a pulsed arterial spin labeling series. Single-voxel proton spectroscopy of the left hippocampus is shared as NIfTI-MRS: the raw folder holds a water-suppressed spin-echo spectrum with its water reference, and a derivatives folder holds MEGA-PRESS edit-on, edit-off and difference spectra, which the paper used for glutamate and GABA.

Known limitations

  • Single site and scanner, and a narrow age range of 18 to 25 years.
  • Two participants of the analysed sample are not in the release.
  • participants.json still carries template descriptions, so the group codes HS and LS are explained only in the README and paper.
  • No clinical, cognitive or microbiome variables are included.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 139 subjects.

Sex

  • Female 97 70%
  • Male 41 29%
  • Other 1 1%

sex in participants.tsv of the ds007694 BIDS repository (CC0), columns age, sex and group

Modality

  • MRI 139 100%

sub-* folders in File listing and JSON sidecars of the ds007694 BIDS repository (CC0), subjects counted per NIfTI file

Condition

Groups can overlap

  • Healthy control 139 100%

README in OpenNeuro ds007694 snapshot 1.0.2 (dataset_description.json, README, CHANGES and snapshot size)

Scanner vendor

  • Siemens Healthineers 139 100%

Manufacturer in JSON sidecars in File listing and JSON sidecars of the ds007694 BIDS repository (CC0), subjects counted per NIfTI file

Country

  • Switzerland 139 100%

Methods, Multimodal Neuroimaging in Iseli et al. 2025, Biological Psychiatry Global Open Science 5(6):100567

Age

mean 21.9 ± 1.9, median 22, range 18 to 25

0
50
100
120
10-1920-29

age in participants.tsv of the ds007694 BIDS repository (CC0), columns age, sex and group

Contrast / sequence

Groups can overlap

  • T1-weighted 137 99%
  • BOLD fMRI 137 99%
  • Arterial spin labeling 137 99%

anat/*_T1w.nii.gz, func/*_task-rest_bold.nii.gz, perf/*_asl.nii.gz in File listing and JSON sidecars of the ds007694 BIDS repository (CC0), subjects counted per NIfTI file

Field strength

  • 3 T 139 100%

Methods, Multimodal Neuroimaging in Iseli et al. 2025, Biological Psychiatry Global Open Science 5(6):100567

Contrast combinations

How many subjects have exactly each set of contrasts.

T1wboldaslSubjects with exactly this set
136
1
1

anat/func/perf NIfTI files in File listing and JSON sidecars of the ds007694 BIDS repository (CC0), subjects counted per NIfTI file

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
Open download

Download without an account

Access page

Creative Commons Zero 1.0 Universal

Public domain dedication. Do anything with the data, including commercial use, without asking and without having to give credit.

dataset_description.json of snapshot 1.0.2 states "License" CC0. Its HowToAcknowledge field asks users to cite the original publication and to contact the authors about co-authorship for substantial reuse.

Original license text Version read: 1.0 Checked 2026-10-07

What you can do

  • Yes
  • Yes
  • Yes
  • Yes
  • Yes

What you can share

  • Yes
  • Yes
  • Yes

What you must do

  • No
  • Share alike No
  • No
  • No
  • Manuscript review No
  • Release code No
  • Return results No
  • Delete after use No

Limits

  • No
  • Location limits No

Citation

Iseli GC, Vázquez-Castellanos JF, Coynel D, Stone JM, Zurita Soler M, Allen P, Zelaya F, Derrien M, Lang UE, Debbané M, Ettinger U, Raes J, Schmidt A. A Multimodal Observational Case-Control Study Exploring Gut Microbiota-Hippocampus Alterations in Individuals With High Positive Schizotypy From the General Population. Biol Psychiatry Glob Open Sci. 2025;5(6):100567. doi:10.1016/j.bpsgos.2025.100567

Sources

Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.