Depression eyes-closed resting-state fMRI (ds002748)
Resting state with closed eyes for patients with depression and healthy participants
Eyes-closed resting-state fMRI and T1-weighted brain MRI of adults with mild to moderate depression and healthy volunteers, collected in Novosibirsk to compare brain network connectivity between the groups. 72 participants in BIDS under CC0, with depression and rumination scores.
Overview
This OpenNeuro release holds the baseline resting-state scans from a Novosibirsk study of brain network connectivity in mild to moderate depression. Dmitry Bezmaternykh, Mikhail Melnikov and colleagues compared functional connectivity between independent components, such as the default mode and executive control networks, in patients and healthy volunteers, and followed subgroups through psychotherapy or fMRI neurofeedback. Each participant contributes one eyes-closed resting-state BOLD run and one T1-weighted anatomical image, shared in BIDS under CC0. It suits work on resting-state markers of depression in a small single-site sample.
Composition
72 adults: 51 outpatients diagnosed with a mild or moderate depressive episode or dysthymia under ICD-10, and 21 healthy volunteers. 53 are women and 19 men. Ages in the participants table run from 19 to 55, with a mean of about 33 in both groups. Every subject has one T1w and one BOLD run; there are no session folders. The participants table carries ICD-10 code, Raven IQ, Beck and Zung depression scores, alexithymia, social desirability, attachment and rumination scales. MADRS, the Hospital Anxiety and Depression Scale and handedness are filled in mainly for the later-recruited patients.
Acquisition
All scans come from one Philips Ingenia 3 T scanner at the International Tomography Center in Novosibirsk. The functional run is a single-shot T2*-weighted echo planar sequence with 2 x 2 x 5 mm voxels, TR 2500 ms, TE 35 ms, flip angle 90 degrees and 25 slices; the dataset README gives 100 volumes per run. Participants lay still with eyes closed. The anatomical image is a 3D T1-weighted turbo field echo with 1 mm isotropic voxels.
Annotations
There are no image labels. Group membership and ICD-10 codes come from clinical diagnosis, with questionnaire scores as phenotype.
Known limitations
- The repeat scans of the 29 patients followed over 2 to 3 months, with or without treatment, are not part of this release.
- The paper excluded one patient for head motion and one for scanner artifacts, but does not say which subjects.
- The paper describes a 6 minute eyes-closed instruction, while 100 volumes at TR 2.5 s cover a little over 4 minutes.
- Single site, single scanner, and a modest number of controls.
- One patient has no ICD-10 code in the participants table.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 72 subjects.
Contrast / sequence
Groups can overlap
- T1-weighted 72 100%
- BOLD fMRI 72 100%
file listing in OpenNeuro ds002748 snapshot 1.0.5 (dataset_description.json, README, task-rest_bold.json, file listing and snapshot size)
Scanner vendor
- Philips 72 100%
Condition by sex
Reported cross table. A dot marks a cell the source does not give.
| Female | Male | |
|---|---|---|
| Major depressive disorder | 38 | 13 |
| Healthy control | 15 | 6 |
Age
mean 33.1, range 19 to 55
age column in participants.tsv of ds002748 snapshot 1.0.5 (CC0); columns participant_id, age, gender and group
Condition
Groups can overlap
- Major depressive disorder 51 71%Age mean 33.1 ± 9.5
- Healthy control 21 29%Age mean 33.8 ± 8.5
Section 2.1 and Table 1, Table 1 in Bezmaternykh et al. 2021, Brain Networks Connectivity in Mild to Moderate Depression: Resting State fMRI Study with Implications to Nonpharmacological Treatment, Neural Plasticity
Age by condition
Reported cross table. A dot marks a cell the source does not give.
| Major depressive disorder | Healthy control | |
|---|---|---|
| 20-29 | 21 | · |
| 30-39 | 16 | 10 |
| 40-49 | 10 | · |
group and age columns in participants.tsv of ds002748 snapshot 1.0.5 (CC0); columns participant_id, age, gender and group
Age by sex
Reported cross table. Missing cells were not published (fewer than 10 or not reported).
- 1140-49n/a
- 1730-39n/a
- 2120-29n/a
gender and age columns in participants.tsv of ds002748 snapshot 1.0.5 (CC0); columns participant_id, age, gender and group
Contrast combinations
How many subjects have exactly each set of contrasts.
| T1w | bold | Subjects with exactly this set |
|---|---|---|
72 |
file listing in OpenNeuro ds002748 snapshot 1.0.5 (dataset_description.json, README, task-rest_bold.json, file listing and snapshot size)
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Download without an account
Creative Commons Zero 1.0 Universal
Public domain dedication. Do anything with the data, including commercial use, without asking and without having to give credit.
dataset_description.json of snapshot 1.0.5 states "License" CC0.
What you can do
- Yes
- Yes
- Yes
- Yes
- Yes
What you can share
- Yes
- Yes
- Yes
What you must do
- No
- Share alike No
- No
- No
- Manuscript review No
- Release code No
- Return results No
- Delete after use No
Limits
- No
- Location limits No
Citation
Bezmaternykh DD, Melnikov MY, Savelov AA, Kozlova LI, Petrovskiy ED, Natarova KA, Shtark MB. Brain Networks Connectivity in Mild to Moderate Depression: Resting State fMRI Study with Implications to Nonpharmacological Treatment. Neural Plasticity 2021, 8846097 (2021). doi:10.1155/2021/8846097
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.
- Bezmaternykh et al. 2021, Brain Networks Connectivity in Mild to Moderate Depression: Resting State fMRI Study with Implications to Nonpharmacological Treatment, Neural Plasticity paper
- OpenNeuro ds002748 snapshot 1.0.5 (dataset_description.json, README, task-rest_bold.json, file listing and snapshot size) website
- participants.tsv of ds002748 snapshot 1.0.5 (CC0); columns participant_id, age, gender and group computed