NIMH movie-watching fMRI in autism (Ramot 2020)
fMRI dataset for "Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality"
Multi-echo functional MRI recorded while young people with autism and typically developing peers watched a social movie scene, used to relate brain response typicality to eye movement typicality. 99 participants, with an anatomical scan each.
Overview
This release holds the movie-watching functional MRI from a study at the National Institute of Mental Health (NIMH) on how young people with autism and typically developing peers orient to and make sense of social scenes. Ramot et al. (2020) measured how closely each person's brain response to the movie matched the group average, and compared that with how typical their eye movements were on a separate set of short clips watched outside the scanner. The fMRI data were posted on NIH figshare in January 2020 under CC BY 4.0.
Composition
99 participants aged 15 to 30: 36 males with autism and 63 typically developing participants, 24 of them female. Mean age was 20.7 in the autism group and 22.05 in the typically developing group. Autism diagnoses rested on DSM-IV criteria with ADI-R and/or ADOS cutoffs given by a research-reliable clinician, and all full-scale IQ scores were above 94. The paper analysed 62 of the typically developing participants after excluding one for abnormal brain structure, and picked 36 of them as a male control group matched on age, IQ and head motion.
Acquisition
Scans were acquired on a GE MR-750 3 T system with a 32-channel head coil. Each participant has a structural MPRAGE and one multi-echo EPI run (TR 2 s, 3 mm voxels, three echoes at 17.5, 35.3 and 53.1 ms, 28 slices, 285 volumes) recorded during a 9.5 minute scene from The Princess Bride with sound. The slice coverage did not include the whole brain, with parts of motor cortex missing. Files are anonymised NIfTI, one per echo, packed in three archives.
Annotations
No image annotations. Group membership (autism or typically developing) is encoded in the file names. Eye tracking recordings from the same participants are separate records in the figshare collection.
Known limitations
- The autism group is all male, so sex is confounded with diagnosis unless the matched male control subset is used.
- Partial field of view in the functional runs.
- The figshare record does not include a participant table; age, sex and IQ per subject are not part of this release as far as the record describes.
- One typically developing participant has abnormal brain structure and was left out of the published analyses.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 99 subjects.
Sex
- Female 24 24%
- Male 75 76%
Methods, Participants in Ramot et al. 2020, Communications Biology 3:48
Contrast / sequence
Groups can overlap
- BOLD fMRI 99 100%
- T1-weighted 99 100%
From NIH figshare record 10688180, fMRI dataset (description and file list)
Scanner vendor
- GE HealthCare 99 100%
Methods, Imaging data collection in Ramot et al. 2020, Communications Biology 3:48
Field strength
- 3 T 99 100%
Methods, Imaging data collection in Ramot et al. 2020, Communications Biology 3:48
Condition by sex
Reported cross table. A dot marks a cell the source does not give.
| Female | Male | |
|---|---|---|
| Autism spectrum disorder | · | 36 |
| Healthy control | 24 | · |
Methods, Participants in Ramot et al. 2020, Communications Biology 3:48
Age
range 15 to 30
No age bins reported.
Methods, Participants in Ramot et al. 2020, Communications Biology 3:48
Condition
Groups can overlap
- Healthy control 63 64%Age mean 22.1, range 15 to 30
- Autism spectrum disorder 36 36%Age mean 20.7, range 15 to 30
Methods, Participants in Ramot et al. 2020, Communications Biology 3:48
Country
- United States 99 100%
Methods, Participants in Ramot et al. 2020, Communications Biology 3:48
Contrast combinations
How many subjects have exactly each set of contrasts.
| T1w | bold | Subjects with exactly this set |
|---|---|---|
99 |
From NIH figshare record 10688180, fMRI dataset (description and file list)
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Download without an account
Direct download from NIH figshare without an account, as three archives (autism group, and two archives for the typically developing group). Eye tracking data are published as separate records in the same figshare collection (doi:10.35092/yhjc.c.4741556).
Creative Commons Attribution 4.0 International
Use, share and adapt the data for any purpose, including commercial use, as long as you credit the creators.
What you can do
- Yes
- Yes
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- Yes
- Yes
What you can share
- Yes
- Yes
- Yes
What you must do
- Yes
- Share alike No
- No
- No
- Manuscript review No
- Release code No
- Return results No
- Delete after use No
Limits
- No
- Location limits No
Citation
Ramot M, Walsh C, Reimann GE, Martin A. Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality. Communications Biology 3, 48 (2020). doi:10.1038/s42003-020-0771-1
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.