NIMH Child Psychiatry Branch Brain Development Study
Child Psychiatry Branch of the National Institute of Mental Health longitudinal structural MRI study of human brain development
Longitudinal structural brain MRI from the NIMH Child Psychiatry Branch since 1989: over 6000 scans of over 2000 youth, about half typically developing and half with ADHD, autism or childhood-onset schizophrenia. No public release of the images was found.
Overview
The Child Psychiatry Branch of the US National Institute of Mental Health (NIMH) has run a longitudinal structural MRI study of brain development since 1989. Children, adolescents and young adults return to the NIH roughly every two years for an MRI scan, neuropsychological testing and genetic analysis. The study charts how grey matter, white matter, cerebrospinal fluid and cerebellar volumes change from childhood into early adulthood, and compares them with trajectories in ADHD and childhood-onset schizophrenia. The 2015 overview paper describes the cohort and its main findings; no public release of the images was found.
Composition
By August 2014 the database held more than 6000 scans from more than 2000 participants. About half were typically developing and about half came from clinical groups, mainly ADHD, autism and childhood-onset schizophrenia (COS). More than 800 scans came from twins. The normative results in the paper use 1171 scans of 618 typically developing males and females aged 5 to 25 years. The COS group, defined by psychosis onset before age 13, had 102 cases at the time of writing. The paper gives no breakdown of the total by sex, age or diagnosis.
Acquisition
Participants were scanned at the NIH, with repeat visits at about two-year intervals. The overview paper does not state the scanner model, field strength or sequence parameters. Structures were measured with automated software such as FreeSurfer, with hand tracing for some structures.
Known limitations
- No public release of the images was found, and no license or data use terms are published.
- Totals are approximate and dated to August 2014; the study continued afterwards.
- The overview paper reports no acquisition protocol, so scanner and contrast details are missing from this entry.
- Counts for ADHD and autism participants are not given.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 2,000 subjects.
Condition
subjects, values can overlap
- Healthy control 618 31%
- Schizophrenia 102 5%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
The data are not available outside the institution or study that holds them
The paper has no data availability statement, and no download or request procedure for the images was found.
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
No license or data use terms are published for the images.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Giedd JN, Raznahan A, Alexander-Bloch A, Schmitt E, Gogtay N, Rapoport JL. Child Psychiatry Branch of the National Institute of Mental Health Longitudinal Structural Magnetic Resonance Imaging Study of Human Brain Development. Neuropsychopharmacology 40(1), 43-49 (2015). doi:10.1038/npp.2014.236
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total The paper states "over 2000 subjects" as of August 2014, about half from clinical populations and half typically developing | ~2,000 | giedd2015 Introduction |
| Scans | total The paper states ">6000 scans" as of August 2014, including >800 scans from twins | ~6,000 | giedd2015 Introduction |
| Subjects | condition=healthy Typically developing subjects aged 5 to 25 years used for the normative trajectories; not necessarily every typically developing participant | 618 | giedd2015 Introduction |
| Scans | condition=healthy Longitudinal scans of the 618 typically developing subjects aged 5 to 25 years | 1,171 | giedd2015 Introduction |
| Subjects | condition=schizophrenia Childhood-onset schizophrenia cases to date (onset of psychosis before age 13) | 102 | giedd2015 Childhood-Onset Schizophrenia |
Sources
The keys used in the table above.
- giedd2015 Giedd et al. 2015, Neuropsychopharmacology (PMC4262916) paper