MGH CAA cohort, cSS evolution set
Massachusetts General Hospital probable cerebral amyloid angiopathy cohort, cortical superficial siderosis evolution set
Baseline and follow-up brain MRI of patients with probable cerebral amyloid angiopathy and no prior brain bleed, rated for siderosis progression and new microbleeds, used to show that siderosis progression predicts a first bleed. 118 patients from Massachusetts General Hospital. Not public.
Overview
This set comes from the prospective cohort of patients with cerebral amyloid angiopathy (CAA) seen at Massachusetts General Hospital in Boston, the group that developed the Boston criteria. It contains patients who presented without intracerebral haemorrhage and had at least two MRI scans, and it was used to show that progression of cortical superficial siderosis (cSS) predicts a first symptomatic lobar haemorrhage. The images and ratings are not public.
Composition
118 patients with probable CAA by the modified Boston criteria, seen in the stroke service or memory clinic between March 2000 and November 2015. 72 presented with transient focal neurological episodes and 46 with cognitive complaints. Mean age 73 years, 75 men. 52 had cSS on the baseline scan. The median interval between the first and last MRI was 2.2 years. They were selected from 261 eligible patients; 143 without an adequate follow-up MRI were excluded.
Acquisition
All scans were acquired at 1.5 T with T2-weighted, T2*-weighted gradient echo (5 mm slices) and FLAIR (5 mm slices) sequences. For 21 patients the blood-sensitive sequence was SWI (1.5 mm slices). Follow-up scans used the same protocol and were done for routine clinical follow-up or new symptoms.
Annotations
Two trained raters scored baseline markers following STRIVE: microbleed count, cSS (none, focal or disseminated), centrum semiovale perivascular spaces and Fazekas grades; WMH volume was measured semi-automatically on FLAIR. cSS progression was graded on a new 0 to 4 scale and new microbleeds on a 0 to 4 scale, by consensus of two raters. All labels are scan-level ratings; there are no masks.
Known limitations
- No public access route, license or data use terms.
- Requiring a follow-up MRI from clinical care selects patients; excluded patients were older and had less cSS at baseline.
- The blood-sensitive sequence differs between patients and sometimes between baseline and follow-up (T2*-GRE or SWI).
- Scanner vendor and model are not reported.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 118 subjects.
Sex
- Female 43 36%
- Male 75 64%
Table 1 in Charidimou et al. 2019, Stroke (author manuscript PMC6433512)
Condition
Groups can overlap
- Cerebral amyloid angiopathy 118 100%
- Superficial siderosis 52 44%
Methods, Results in Charidimou et al. 2019, Stroke (author manuscript PMC6433512)
Country
- United States 118 100%
Methods in Charidimou et al. 2019, Stroke (author manuscript PMC6433512)
Age
mean 73 ± 8.3
No age bins reported.
Table 1 in Charidimou et al. 2019, Stroke (author manuscript PMC6433512)
Contrast / sequence
Groups can overlap
- Susceptibility-weighted 21 18%
Methods in Charidimou et al. 2019, Stroke (author manuscript PMC6433512)
Field strength
- 1.5 T 118 100%
Methods in Charidimou et al. 2019, Stroke (author manuscript PMC6433512)
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Ask the authors or the data holder. No published process or terms, and access is at their discretion
The paper states that the supporting data are in the article and its supplement; it offers no access to the images. Any request goes to the authors.
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
The paper publishes no license or data use terms for the images or ratings.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Charidimou A, Boulouis G, Xiong L, et al. Cortical Superficial Siderosis Evolution. Stroke 50(4), 954-962 (2019). doi:10.1161/STROKEAHA.118.023368
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.