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Open Imaging Index
MRI Brain

MCIC

MIND Clinical Imaging Consortium (MCIC) collection

Four-site US study of 162 people with schizophrenia and 169 matched controls with raw DICOM T1w, T2w, diffusion and task fMRI plus clinical and cognitive data. Data from three of the sites are shared through COINS under a data use agreement.

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Overview

The MIND Clinical Imaging Consortium (MCIC) ran a cross-sectional study at four US sites between 2004 and 2006 to find neuroimaging markers of schizophrenia. The consortium, coordinated by the Mind Research Network in Albuquerque, shares raw DICOM images together with clinical, demographic and neuropsychological data through the COINS Data Exchange. The collection is intended for schizophrenia research, for testing registration and segmentation software, and for teaching.

Composition

The study recruited 188 patients and 190 healthy controls. Data are available for 162 patients and 169 controls (331 subjects), aged 18 to 60 at inclusion. Patients met DSM-IV criteria for schizophrenia, schizoaffective disorder or schizophreniform disorder, and recruitment favoured people early in their illness. Controls were matched within site for age, sex and parental education. The paper reports structural MRI for 327 subjects and diffusion MRI for 289. Of the four sites, only three are publicly released; the paper does not say which site is withheld, so the counts in this entry describe the full four-site cohort and overstate the shared subset.

Acquisition

Sites used 1.5T and 3T scanners: a 1.5T Siemens Sonata, a 3T Siemens Trio, a 1.5T Siemens paired with a 3T Trio for fMRI, and a 1.5T GE Signa paired with a 3T Trio. Each subject had coronal T1-weighted scans (two or three volumes) and two coronal T2-weighted TSE volumes, a diffusion scan with 6 to 60 directions depending on site, and EPI fMRI for a Sternberg working memory task, a sensorimotor task, an auditory oddball task and a breath hold task. Task timing and E-Prime response files are included. DICOM headers are scrubbed and subjects carry anonymous IDs.

Known limitations

  • Single time point, no follow-up.
  • Diffusion protocols differ between sites, and structural scans mix field strengths and vendors.
  • Reaction times from one site are unusable because of a button box setup error.
  • Genetic data collected in the study are not part of the release.
  • The data use agreement is sent after a request and its text is not published.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 331 subjects.

Sex

  • Female 106 100%

Covers 106 of 331 subjects.

Contrast / sequence

subjects, values can overlap

  • T1-weighted 327 99%
  • Diffusion-weighted 289 87%

Condition

subjects, values can overlap

  • Healthy control 169 51%
  • Schizophrenia 162 49%

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
Signed agreement

Sign a data use agreement, often reviewed by the provider

Access page

MCIC Data Use Agreement

Users request the data through the COINS Data Exchange and must accept the MCIC Data Use Agreement before they can download. The data providers describe the data as free to use without restrictions and ask, without requiring it, that users cite the paper and the sharing site. The agreement text itself is not published, so most rules are unspecified.

Original license text Version read: Agreement text not published. Terms as described in the Information Sharing Statement of Gollub et al. 2013 and on the NITRC project page, read 2026-10-09 Checked 2026-10-09

What you can do

  • Not stated
  • Not stated
  • Train ML models Not stated
  • Create derived data Not stated
  • Publish results Not stated

What you can share

  • Share the data Not stated
  • Not stated
  • Share trained models Not stated

What you must do

  • Not stated
  • Share alike Not stated
  • Yes
  • Ethics approval Not stated
  • Manuscript review Not stated
  • Release code Not stated
  • Return results Not stated
  • Delete after use Not stated

Limits

  • No re-identification Not stated
  • Location limits Not stated

Citation

Gollub RL, Shoemaker JM, King MD, et al. The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia. Neuroinformatics 11(3):367-388 (2013). doi:10.1007/s12021-013-9184-3

All numbers

Every number on this page, as stored in stats.csv, with its source.

MeasureBreakdownValueSource
Subjectstotal
Four-site study cohort with data; the paper states that one site's data is not publicly released, without naming the site, so the shared subset is smaller
331gollub2013
Table 1
Subjectscondition=schizophrenia
Four-site cohort; schizophrenia, schizoaffective or schizophreniform disorder
162gollub2013
Table 1
Subjectscondition=healthy
Four-site cohort
169gollub2013
Table 1
Subjectscontrast=T1w
Four-site cohort; sMRI column (coronal T1w and T2w collected in each structural session)
327gollub2013
Table 1
Subjectscontrast=dwi
Four-site cohort
289gollub2013
Table 1; Diffusion Weighted Imaging Data
Subjectscondition=healthy;contrast=T1w
Four-site cohort; sMRI column
169gollub2013
Table 1
Subjectscondition=schizophrenia;contrast=T1w
Four-site cohort; sMRI column
158gollub2013
Table 1
Subjectscondition=healthy;contrast=dwi
Four-site cohort
153gollub2013
Table 1
Subjectscondition=schizophrenia;contrast=dwi
Four-site cohort
136gollub2013
Table 1
Subjectssex=female
Sum of 64 female controls and 42 female patients; Table 2 lists 169 controls and 161 patients
106gollub2013
Table 2
Subjectssex=female;condition=healthy
Four-site cohort
64gollub2013
Table 2
Subjectssex=female;condition=schizophrenia
Four-site cohort; Table 2 lists 161 patients
42gollub2013
Table 2
Mean agecondition=healthy
Four-site cohort
31.5gollub2013
Table 2
Age SDcondition=healthy
Four-site cohort
11.1gollub2013
Table 2
Mean agecondition=schizophrenia
Four-site cohort
33.5gollub2013
Table 2
Age SDcondition=schizophrenia
Four-site cohort
10.8gollub2013
Table 2

Sources

The keys used in the table above.