LINCHPIN CT and pathology set
Lothian IntraCerebral Haemorrhage, Pathology, Imaging and Neurological Outcome (LINCHPIN) study, CT and neuropathology data
Head CT ratings, APOE genotype and autopsy grading of cerebral amyloid angiopathy from adults who died after intracerebral haemorrhage, used to derive the Edinburgh criteria for CAA-related bleeds. 110 adults from Lothian, Scotland. The ratings are open; the CT images are not shared.
Overview
LINCHPIN is a prospective, population-based inception cohort of adults with spontaneous intracerebral haemorrhage in the Lothian region of Scotland, run by the Centre for Clinical Brain Sciences at the University of Edinburgh. This entry covers the part of the cohort with a research autopsy, which was used to derive the Edinburgh CT and genetic criteria for lobar haemorrhage caused by cerebral amyloid angiopathy (CAA). The table of CT ratings, APOE genotype and neuropathology ratings is an open download; the CT images themselves are not shared.
Composition
110 adults with a first-ever intracerebral haemorrhage confirmed on CT, who died and underwent research autopsy between June 2010 and February 2016. Median age 83 years, 49 men. The haemorrhage was lobar in 62, deep in 41 and infratentorial in 7. Among the lobar cases, 36 had moderate or severe CAA and 26 absent or mild CAA. The wider LINCHPIN incidence study counted 128 adults with first-ever primary haemorrhage in 2010 to 2011 in a population of 695,335 adults.
Acquisition
Each participant had a non-contrast head CT that diagnosed the haemorrhage, with a median of 5 hours from onset to CT. Median time from CT to autopsy was 11 days. APOE genotype came from blood (28) or post-mortem cerebellar tissue (82).
Annotations
Two neuroradiologists rated the reformatted CT on a standard form, masked to clinical, genetic and pathological data: haemorrhage location, subarachnoid, subdural and intraventricular extension, finger-like projections and other features. A neuropathologist graded parenchymal and meningeal CAA and other small vessel disease in the left hemisphere. Labels are case-level ratings; there are no voxel masks.
Known limitations
- The CT images are not available; only the ratings table and the analysis code are public.
- Only people who died and consented to autopsy are included, so the set is older and more severely affected than the full cohort.
- No MRI is part of this set; only seven lobar cases had an MRI within six months.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 110 subjects.
Condition
Groups can overlap
- Intracerebral hemorrhage 110 100%
- Cerebral amyloid angiopathy 42 38%
Results, Results and Figure 1 in Rodrigues et al. 2018, Lancet Neurology (PMC5818029)
Contrast / sequence
Groups can overlap
- Non-contrast CT 110 100%
Results in Rodrigues et al. 2018, Lancet Neurology (PMC5818029)
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Ask the authors or the data holder. No published process or terms, and access is at their discretion
The table of CT ratings, APOE genotype and neuropathology ratings is an open download on Edinburgh DataShare. The CT images are not part of that record, and no route to them is published.
Different parts of the data carry different licenses. The summary on the right shows the most restrictive answer per rule.
Creative Commons Attribution 4.0 International
Use, share and adapt the data for any purpose, including commercial use, as long as you credit the creators.
What you can do
- Yes
- Yes
- Yes
- Yes
- Yes
What you can share
- Yes
- Yes
- Yes
What you must do
- Yes
- Share alike No
- No
- No
- Manuscript review No
- Release code No
- Return results No
- Delete after use No
Limits
- No
- Location limits No
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Rodrigues MA, Samarasekera N, Lerpiniere C, et al. The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. Lancet Neurology 17(3), 232-240 (2018). doi:10.1016/S1474-4422(18)30006-1
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.