LINCHPIN CT and pathology set
Lothian IntraCerebral Haemorrhage, Pathology, Imaging and Neurological Outcome (LINCHPIN) study, CT and neuropathology data
Admission non-contrast head CT of 110 adults with first-ever intracerebral haemorrhage in Lothian, Scotland, who died and had a research autopsy, with masked CT ratings, APOE genotype and CAA grading. The ratings are open; the CT images are not shared.
Overview
LINCHPIN is a prospective, population-based inception cohort of adults with spontaneous intracerebral haemorrhage in the Lothian region of Scotland, run by the Centre for Clinical Brain Sciences at the University of Edinburgh. This entry covers the part of the cohort with a research autopsy, which was used to derive the Edinburgh CT and genetic criteria for lobar haemorrhage caused by cerebral amyloid angiopathy (CAA). The table of CT ratings, APOE genotype and neuropathology ratings is an open download; the CT images themselves are not shared.
Composition
110 adults with a first-ever intracerebral haemorrhage confirmed on CT, who died and underwent research autopsy between June 2010 and February 2016. Median age 83 years, 49 men. The haemorrhage was lobar in 62, deep in 41 and infratentorial in 7. Among the lobar cases, 36 had moderate or severe CAA and 26 absent or mild CAA. The wider LINCHPIN incidence study counted 128 adults with first-ever primary haemorrhage in 2010 to 2011 in a population of 695,335 adults.
Acquisition
Each participant had a non-contrast head CT that diagnosed the haemorrhage, with a median of 5 hours from onset to CT. Median time from CT to autopsy was 11 days. APOE genotype came from blood (28) or post-mortem cerebellar tissue (82).
Annotations
Two neuroradiologists rated the reformatted CT on a standard form, masked to clinical, genetic and pathological data: haemorrhage location, subarachnoid, subdural and intraventricular extension, finger-like projections and other features. A neuropathologist graded parenchymal and meningeal CAA and other small vessel disease in the left hemisphere. Labels are case-level ratings; there are no voxel masks.
Known limitations
- The CT images are not available; only the ratings table and the analysis code are public.
- Only people who died and consented to autopsy are included, so the set is older and more severely affected than the full cohort.
- No MRI is part of this set; only seven lobar cases had an MRI within six months.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 110 subjects.
Sex
- Male 49 45%
- Female 61 55%
Contrast / sequence
subjects, values can overlap
- Non-contrast CT 110 100%
Condition
subjects, values can overlap
- Intracerebral hemorrhage 110 100%
- Cerebral amyloid angiopathy 42 38%
Country
subjects
- United Kingdom 110 100%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Ask the authors or the data holder. No published process or terms, and access is at their discretion
The table of CT ratings, APOE genotype and neuropathology ratings is an open download on Edinburgh DataShare. The CT images are not part of that record, and no route to them is published.
Different parts of the data carry different licenses. The summary on the right shows the most restrictive answer per rule.
Creative Commons Attribution 4.0 International
Use, share and adapt the data for any purpose, including commercial use, as long as you credit the creators.
What you can do
- Yes
- Yes
- Yes
- Yes
What you can share
- Yes
- Yes
- Yes
What you must do
- Yes
- Share alike No
- No
- No
- Manuscript review No
- Release code No
- Return results No
- Delete after use No
Limits
- No
- Location limits No
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
What you can do
- Commercial use Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Rodrigues MA, Samarasekera N, Lerpiniere C, et al. The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. Lancet Neurology 17(3), 232-240 (2018). doi:10.1016/S1474-4422(18)30006-1
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total adults with first-ever CT-diagnosed intracerebral haemorrhage who had a research autopsy (June 2010 to February 2016) | 110 | rodrigues2018 Results |
| Subjects | sex=male | 49 | rodrigues2018 Results |
| Subjects | sex=female 110 participants minus 49 men; the paper reports men only | 61 | rodrigues2018 Results |
| Subjects | condition=intracerebral_hemorrhage lobar 62, deep 41, infratentorial 7 | 110 | rodrigues2018 Results |
| Subjects | condition=cerebral_amyloid_angiopathy moderate or severe CAA: 36 of 62 lobar and 6 of 48 non-lobar haemorrhages; the two groups are disjoint | 42 | rodrigues2018 Results and Figure 1 |
| Subjects | contrast=ct_noncontrast non-contrast head CT that diagnosed the haemorrhage | 110 | rodrigues2018 Results |
| Subjects | country=GB Lothian health board region, Scotland | 110 | rodrigues2018 Methods |
| Median age | total IQR 76-87 | 83 | rodrigues2018 Results |
Sources
The keys used in the table above.
- rodrigues2018 Rodrigues et al. 2018, Lancet Neurology (PMC5818029) paper
- datashare-linchpin-ct-pathology Rodrigues and Al-Shahi Salman, LINCHPIN CT and pathology data, Edinburgh DataShare record data
- samarasekera2015 Samarasekera et al. 2015, Stroke, LINCHPIN population-based incidence study paper