KNE96 Korean Normal Elderly template cohort
Korean Normal Elderly (KNE) brain MRI template study, KLOSCAD subsample
Structural brain MRI of cognitively normal older Korean adults, used to build elderly brain templates for spatial normalization in Asian populations. 144 people aged 60 or older; only the derived templates were released, not the scans.
Overview
The Korean Normal Elderly (KNE) template study scanned 144 cognitively normal Korean adults drawn from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD), a population-based cohort started in 2009. The goal was an elderly, ethnically matched brain template for spatial normalization, as an alternative to young Western templates such as ICBM152. The authors released three derived group templates: KNE96 (all 96 construction subjects), KNE48M (the 48 men) and KNE48F (the 48 women). The individual scans were not released, and the paper gives no route to request them. The template download page named in the paper now returns 404.
Composition
144 right-handed participants aged 60 years or older, all rated CDR 0. People with a DSM-IV Axis I disorder or a serious medical or neurological disorder that could affect cognition were excluded. A construction group of 96 (48 men, mean age 69.5; 48 women, mean age 70.1) built the templates, and a separate validation group of 48 (24 men, 24 women) tested them. The study was approved by the Institutional Review Board of Seoul National University Bundang Hospital.
Acquisition
Scans were 3D T1-weighted spoiled gradient echo (SPGR) images acquired on a 3 T GE SIGNA system: sagittal 1 mm slices, 1 mm isotropic voxels, TR 25 ms, TE 3.68 ms, flip angle 30 degrees, 24 cm field of view. Images were stored as DICOM and converted to ANALYZE for processing.
Annotations
No manual labels. The templates were built with the DARTEL toolbox in SPM8. For validation, the 48 held-out scans were registered to KNE96 and to ICBM152, and the deformations (displacement magnitude and log Jacobian determinant) were compared by brain region. Registration to KNE96 needed smaller deformations in most regions.
Known limitations
- Subject scans are not shared and no data use terms were published; only the templates were offered.
- The template download page no longer resolves, so the templates are also unavailable from the original source.
- One contrast (T1w) on one scanner model; age is reported only as mean and standard deviation per group.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 144 subjects.
Condition
Groups can overlap
- Healthy control 144 100%
Study population in Lee et al. 2016, Psychiatry Investigation 13(1)
Field strength
- 3 T 144 100%
Image acquisition and preparation in Lee et al. 2016, Psychiatry Investigation 13(1)
Age
from 60
No age bins reported.
Study population in Lee et al. 2016, Psychiatry Investigation 13(1)
Contrast / sequence
Groups can overlap
- T1-weighted 144 100%
Image acquisition and preparation in Lee et al. 2016, Psychiatry Investigation 13(1)
Scanner vendor
- GE HealthCare 144 100%
Image acquisition and preparation in Lee et al. 2016, Psychiatry Investigation 13(1)
Sex by split
Reported cross table. A dot marks a cell the source does not give.
| Training | Validation | |
|---|---|---|
| Female | 48 | 24 |
| Male | 48 | 24 |
Other reported numbers 8
| Mean age · Training, Male | 69.5 | Table 1 in Lee et al. 2016, Psychiatry Investigation 13(1) |
| Age SD · Training, Male | 6.2 | Table 1 in Lee et al. 2016, Psychiatry Investigation 13(1) |
| Mean age · Training, Female | 70.1 | Table 1 in Lee et al. 2016, Psychiatry Investigation 13(1) |
| Age SD · Training, Female | 7 | Table 1 in Lee et al. 2016, Psychiatry Investigation 13(1) |
| Mean age · Validation, Male | 71.5 | Table 1 in Lee et al. 2016, Psychiatry Investigation 13(1) |
| Age SD · Validation, Male | 5.9 | Table 1 in Lee et al. 2016, Psychiatry Investigation 13(1) |
| Mean age · Validation, Female | 72.8 | Table 1 in Lee et al. 2016, Psychiatry Investigation 13(1) |
| Age SD · Validation, Female | 5.1 | Table 1 in Lee et al. 2016, Psychiatry Investigation 13(1) |
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
The data are not available outside the institution or study that holds them
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
The paper offers only the three group templates for download, from a lab web page that now returns 404. It states no terms for the subject scans and does not invite requests for them. The CC BY-NC 3.0 license of the article covers the paper, not the data.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Lee H, Yoo BI, Han JW, Lee JJ, Oh SYW, Lee EY, Kim JH, Kim KW. Construction and Validation of Brain MRI Templates from a Korean Normal Elderly Population. Psychiatry Investigation 13(1), 135-145 (2016). doi:10.4306/pi.2016.13.1.135
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.