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MRI Brain

Hepatic encephalopathy brain MRI radiomics (ISMETT)

Raw Data for the article: Brain magnetic resonance imaging radiomics features associated with hepatic encephalopathy in adult cirrhotic patients

Brain MRI of adult cirrhotic patients and non-cirrhotic controls from a transplant centre in Palermo, all on one 3T scanner, with texture features of the lentiform nuclei on T1-weighted images used to detect and grade chronic hepatic encephalopathy. 124 patients. Access restricted.

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Overview

This retrospective cohort comes from IRCCS-ISMETT, a tertiary transplant centre in Palermo, Italy. Adults with liver cirrhosis and a control group without chronic liver disease had brain MRI with the same 3T protocol between October 2018 and February 2020. The study asked whether texture features measured in the lentiform nuclei on T1-weighted images can tell cirrhotic patients from controls and detect and grade chronic hepatic encephalopathy. The related Zenodo record holds the raw data for the article under restricted access.

Composition

124 patients were included out of 306 consecutive brain MRI exams screened: 70 with cirrhosis and 54 controls. Cirrhotic patients were 52 men and 18 women, aged 40 to 86 (mean 66.2); controls were 37 men and 17 women, aged 28 to 81 (mean 62.4). Cirrhosis was mostly viral (41), followed by NASH (11), alcohol (10) and other causes (8). 38 cirrhotic patients had chronic hepatic encephalopathy, graded by the West Haven criteria as grade 1 in 16, grade 2 in 16, grade 3 in 4 and grade 4 in 2. MELD scores are reported. Controls were scanned for other reasons, most often chronic hypoxic-ischemic encephalopathy (31) and migraine (11). Patients with a TIPS or with motion on T1-weighted images were excluded.

Acquisition

All exams ran on a GE Discovery 750w 3T scanner with a 32-channel head coil. The protocol had axial, sagittal and coronal fast spin echo T1-weighted images before and after gadobutrol, axial and sagittal T2-weighted images and axial FLAIR. T1-weighted slices were 4 mm thick with a 1 mm gap.

Annotations

A neuroradiologist rated T1 hyperintensity in the globi pallidi. A second radiologist, blinded to clinical data, drew a polygonal ROI in both lentiform nuclei on a single axial non-contrast T1-weighted slice at the level of the foramina of Monro, and 43 texture features were extracted with LIFEx.

Known limitations

  • Not openly available. The Zenodo files are restricted and the paper offers the data only on request. What the record contains (images or extracted features) is not described.
  • Single centre, single scanner, retrospective.
  • Controls are clinical patients with other neurological indications, not healthy volunteers.
  • Texture analysis covers one slice per patient.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 124 subjects.

Sex

  • Female 35 28%
  • Male 89 72%

Table 1 in Sparacia et al. 2022, Neuroradiology 64, 1969-1978

Condition

Groups can overlap

  • Liver cirrhosis 70 56%
    Age mean 66.2 ± 8.4, range 40 to 86
  • Hepatic encephalopathy 38 31%
  • Hypoxic ischemic encephalopathy 31 25%
  • Migraine 11 9%

Table 1, Results (Patients' characteristics) in Sparacia et al. 2022, Neuroradiology 64, 1969-1978

Sex by condition

Reported cross table. A dot marks a cell the source does not give.

Liver cirrhosis
Female18
Male52

Table 1 in Sparacia et al. 2022, Neuroradiology 64, 1969-1978

Contrast / sequence

Groups can overlap

  • T1-weighted 124 100%

MR imaging acquisition in Sparacia et al. 2022, Neuroradiology 64, 1969-1978

Scanner vendor

  • GE HealthCare 124 100%

MR imaging acquisition in Sparacia et al. 2022, Neuroradiology 64, 1969-1978

Field strength

  • 3 T 124 100%

MR imaging acquisition in Sparacia et al. 2022, Neuroradiology 64, 1969-1978

Country

  • Italy 124 100%

Materials and methods in Sparacia et al. 2022, Neuroradiology 64, 1969-1978

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
On request

Ask the authors or the data holder. No published process or terms, and access is at their discretion

The Zenodo record is restricted, lists no files and does not accept access requests through Zenodo. The paper's data availability statement says the data are available if requested. Whether MRI images, ROI data or only the extracted texture features are part of the record is not stated.

Access page

Creative Commons Attribution 4.0 International

Use, share and adapt the data for any purpose, including commercial use, as long as you credit the creators.

The Zenodo record is labelled CC BY 4.0, which applies once access has been granted. No other terms are published.

Original license text Version read: 4.0 Checked 2026-10-07

What you can do

  • Yes
  • Yes
  • Yes
  • Yes
  • Yes

What you can share

  • Yes
  • Yes
  • Yes

What you must do

  • Yes
  • Share alike No
  • No
  • No
  • Manuscript review No
  • Release code No
  • Return results No
  • Delete after use No

Limits

  • No
  • Location limits No

Citation

Sparacia G, Parla G, Cannella R, et al. Brain magnetic resonance imaging radiomics features associated with hepatic encephalopathy in adult cirrhotic patients. Neuroradiology 64, 1969-1978 (2022). doi:10.1007/s00234-022-02949-2

Sources

Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.