GRMPY (ds008579)
Brain MRI with resting-state and task fMRI, diffusion, perfusion and angiography of adolescents and young adults with irritability or borderline personality disorder and typically developing peers, with clinical diagnoses and extensive questionnaires.
Overview
This OpenNeuro dataset shares raw brain MRI from GRMPY, a single-site study at the University of Pennsylvania by the group of Theodore Satterthwaite and funded by grant R01MH107703. Participants were enrolled in three groups: young people with irritability, people with borderline personality disorder and typically developing peers. The release pairs multimodal imaging with clinical diagnoses, n-back task performance and many symptom and cognition questionnaires. Snapshot 1.0.0 was published in August 2026 under a CC0 waiver. The dataset README contains only a title, so the study aims are not described in the release itself.
Composition
The release contains 231 participants with one imaging session each: 136 in the irritability group, 60 typically developing and 35 in the borderline personality disorder group. There are 140 female, 90 male and one participant of another sex, aged 12.6 to 30.9 years (mean 22.0). The participants file holds group, age, sex, race, ethnicity, education, parental education, body mass index, binary DSM diagnostic flags (with remission status) and summary scores of the fractal n-back task. A phenotype folder adds anxiety, depression, mania, anhedonia, sleep, substance use and puberty questionnaires and the Penn Computerized Neurocognitive Battery. Every participant has a T2-weighted image, a time-of-flight angiogram and resting-state fMRI; 230 have a T1-weighted image, 214 arterial spin labeling and 177 diffusion imaging.
Acquisition
All sidecars checked report a Siemens Prisma at 3 T at the University of Pennsylvania. The protocol includes a 1 mm MPRAGE T1-weighted image, a sagittal 3D SPACE T2-weighted image, a 3D multi-slab time-of-flight angiogram with projection images in three planes, multi-shell diffusion imaging (117 directions), arterial spin labeling with M0 scans, multiband and single-band resting-state runs, a fractal n-back working memory task (199 participants) and a face task (48 participants). Field maps are included. Anatomical images are defaced or refaced.
Annotations
There are no image annotations. Derivatives hold group-level n-back activation maps and FreeSurfer-based outputs.
Known limitations
- No data descriptor or study paper is linked from the release, and the README gives no study design.
- Diagnostic flags are missing for 12 participants, and group membership does not match diagnoses one to one: only 15 of the 35 borderline personality disorder group members carry that diagnostic flag.
- The face task covers only 48 participants, and diffusion imaging is missing for 54.
- Acquisition parameters vary between participants, recorded as variant acquisition labels in the file names.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 231 subjects.
Sex
- Female 140 61%
- Male 90 39%
- Other 1 0%
sex in participants.tsv and participants.json of ds008579 snapshot 1.0.0 (CC0), counted per row
Contrast / sequence
Groups can overlap
- T2-weighted 231 100%
- MR angiography 231 100%
- BOLD fMRI 231 100%
- T1-weighted 230 100%
- Arterial spin labeling 214 93%
- Diffusion-weighted 177 77%
sub-*/ses-1/anat/*_T1w.nii.gz, sub-*/ses-1/anat/*_T2w.nii.gz, sub-*/ses-1/anat/*_angio.nii.gz, sub-*/ses-1/func/*_bold.nii.gz, sub-*/ses-1/perf/*_asl.nii.gz, sub-*/ses-1/dwi/*_dwi.nii.gz in File tree and JSON sidecars of ds008579 snapshot 1.0.0 (CC0), NIfTI files counted per subject and BIDS suffix
Age
mean 22 ± 3.5, median 22.2, range 12.6 to 30.9
age in participants.tsv and participants.json of ds008579 snapshot 1.0.0 (CC0), counted per row
Condition
Groups can overlap
- Irritability 136 59%
- Anxiety disorder 83 36%
- Clinical high risk for psychosis 77 33%
- Healthy control 62 27%
- Major depressive disorder 39 17%
- Post-traumatic stress disorder 20 9%
- ADHD 18 8%
- Borderline personality disorder 16 7%
group, dx_brderpd, dx_none, dx_prodromal, dx_psychosis, dx_scz, dx_bp, dx_mdd, dx_anx, dx_adhd, dx_ptsd in participants.tsv and participants.json of ds008579 snapshot 1.0.0 (CC0), counted per row
Age by sex
Reported cross table. Missing cells were not published (fewer than 10 or not reported).
- 10720-2951
- 3010-1939
sex, age in participants.tsv and participants.json of ds008579 snapshot 1.0.0 (CC0), counted per row
Contrast combinations
How many subjects have exactly each set of contrasts.
| T1w | T2w | angio | dwi | bold | asl | Subjects with exactly this set |
|---|---|---|---|---|---|---|
169 | ||||||
45 | ||||||
9 | ||||||
7 | ||||||
1 |
anat, dwi, func and perf folders in File tree and JSON sidecars of ds008579 snapshot 1.0.0 (CC0), NIfTI files counted per subject and BIDS suffix
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Download without an account
Creative Commons Zero 1.0 Universal
Public domain dedication. Do anything with the data, including commercial use, without asking and without having to give credit.
dataset_description.json of snapshot 1.0.0 states "License" CC0.
What you can do
- Yes
- Yes
- Yes
- Yes
- Yes
What you can share
- Yes
- Yes
- Yes
What you must do
- No
- Share alike No
- No
- No
- Manuscript review No
- Release code No
- Return results No
- Delete after use No
Limits
- No
- Location limits No
Citation
Singleton SP, Sevchik BL, Rush S, Brook JBH, Cieslak M, Flook EA, Horien C, Meisler SL, Salo T, Tong TT, Calkins ME, Gur RE, Gur RC, Leibenluft E, Ruparel K, Shinohara RT, Roalf DR, Wolf DH, Satterthwaite TD. GRMPY. OpenNeuro ds008579, version 1.0.0 (2026). doi:10.18112/openneuro.ds008579.v1.0.0
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.