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Open Imaging Index
MRI Brain

Prague Functional Movement Disorder Resting-State fMRI

Centrality and seed-based correlation maps obtained with functional MRI

Resting-state BOLD fMRI of adults with functional movement disorder and healthy controls, used to relate brain network centrality to motor symptom severity. Images are shared on request; per-subject connectivity maps are public.

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Overview

This entry covers the resting-state fMRI cohort behind a 2022 study by Charles University in Prague and the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig. The authors compared voxel-wise network centrality between people with functional movement disorder (FMD) and healthy controls, and between patients with and without functional weakness, and correlated centrality with motor symptom severity. The scans themselves are offered on reasonable request as anonymized pre-processed NIfTI files. What is public is a CC BY 4.0 deposit on Mendeley Data with each participant's connectivity maps and the SPM12 group analyses.

Composition

The cohort has 48 patients with clinically definite FMD and 65 controls. Of the patients, 28 had functional weakness and 20 did not; all had non-paroxysmal motor symptoms. Controls had no signs of neurological disease, but people with depression, anxiety or antidepressant treatment were deliberately included to match common comorbidity in FMD. Mean age was 45.3 years in patients and 46.0 in controls; 37 patients and 41 controls were women.

Acquisition

Every participant had one 10-minute resting-state BOLD run (304 volumes, TR 2 s, 3 mm in-plane resolution, 30 axial slices) on a 3T Siemens MAGNETOM Skyra with a 32-channel head coil, fixating on a crosshair. The same sequence was used for the whole study. Pre-processing used the CONN toolbox and SPM12.

Annotations

Clinical labels include the simplified FMD rating scale, the Beck Depression Inventory, the State-Trait Anxiety Inventory, disease onset and duration, and psychotropic medication. The public deposit holds global correlation (with and without denoising), intrinsic connectivity, two eigenvector centrality variants, and seed-based correlation from the precuneus and the left temporoparietal junction, one NIfTI map per participant each.

Known limitations

  • Raw and pre-processed fMRI are not public, and no terms for the on-request data are published.
  • The public maps are derived values in standard space, not images that can be reprocessed.
  • Single site, single scanner, and a modest sample split further by phenotype.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 113 subjects.

Sex

  • Female 78 69%
  • Male 35 31%

Table 1 in Mueller et al. 2022, NeuroImage Clinical (PMC8921488)

Contrast / sequence

Groups can overlap

  • BOLD fMRI 113 100%

2.2. Image acquisition in Mueller et al. 2022, NeuroImage Clinical (PMC8921488)

Scanner vendor

  • Siemens Healthineers 113 100%

2.2. Image acquisition in Mueller et al. 2022, NeuroImage Clinical (PMC8921488)

Country

  • Czechia 113 100%

2.1. Participants in Mueller et al. 2022, NeuroImage Clinical (PMC8921488)

Modality

  • MRI 113 100%

2.2. Image acquisition in Mueller et al. 2022, NeuroImage Clinical (PMC8921488)

Condition

Groups can overlap

  • Healthy control 65 58%
    Age mean 46 ± 9.4
  • Functional neurological disorder 48 42%
    Age mean 45.3 ± 9.7

Table 1 in Mueller et al. 2022, NeuroImage Clinical (PMC8921488)

Field strength

  • 3 T 113 100%

2.2. Image acquisition in Mueller et al. 2022, NeuroImage Clinical (PMC8921488)

Condition by sex

Reported cross table. A dot marks a cell the source does not give.

FemaleMale
Healthy control4124
Functional neurological disorder3711

Table 1 in Mueller et al. 2022, NeuroImage Clinical (PMC8921488)

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
On request

Ask the authors or the data holder. No published process or terms, and access is at their discretion

The data availability statement of Mueller et al. (2022) says the analysed data are available on reasonable request, with the functional MRI given as anonymized pre-processed NIfTI files. The per-subject connectivity maps (global correlation, intrinsic connectivity, eigenvector centrality and seed-based correlation) and the SPM12 group analyses are an open download on Mendeley Data under CC BY 4.0.

Access page

Different parts of the data carry different licenses. The summary on the right shows the most restrictive answer per rule.

For Per-subject connectivity maps and SPM12 group analyses on Mendeley Data

Creative Commons Attribution 4.0 International

Use, share and adapt the data for any purpose, including commercial use, as long as you credit the creators.

Original license text Version read: 4.0 Checked 2026-10-07

What you can do

  • Yes
  • Yes
  • Yes
  • Yes
  • Yes

What you can share

  • Yes
  • Yes
  • Yes

What you must do

  • Yes
  • Share alike No
  • No
  • No
  • Manuscript review No
  • Release code No
  • Return results No
  • Delete after use No

Limits

  • No
  • Location limits No
For Pre-processed functional MRI, shared on request

No published license or data use terms

The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.

No license or data use terms are stated for the functional MRI data shared on request.

Original license text Checked 2026-10-08

What you can do

  • Commercial use Not stated
  • Not stated
  • Train ML models Not stated
  • Create derived data Not stated
  • Publish results Not stated

What you can share

  • Share the data Not stated
  • Share derived data Not stated
  • Share trained models Not stated

What you must do

  • Cite or credit Not stated
  • Share alike Not stated
  • Sign an agreement Not stated
  • Ethics approval Not stated
  • Manuscript review Not stated
  • Release code Not stated
  • Return results Not stated
  • Delete after use Not stated

Limits

  • No re-identification Not stated
  • Location limits Not stated

Citation

Mueller K, Růžička F, Slovák M, Forejtová Z, Dušek P, Dušek P, Jech R, Serranová T. Symptom-severity-related brain connectivity alterations in functional movement disorders. NeuroImage: Clinical 34, 102981 (2022). doi:10.1016/j.nicl.2022.102981. Data: Mendeley Data, V1 (2022). doi:10.17632/w35fvmtnf2.1

Sources

Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.