EDSD
European DTI Study on Dementia
Diffusion and structural brain MRI of patients with Alzheimer's dementia or MCI and healthy controls, collected to test how well diffusion markers separate the groups and how much they vary between sites. 493 people scanned on 13 scanners at 11 European centres. Access after a data usage agreement.
Overview
The European DTI Study on Dementia (EDSD) is a multicenter collection of diffusion tensor imaging (DTI) and structural brain MRI, set up in 2010 to test how well DTI markers separate patients with Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI) from healthy controls, and how much these markers vary between sites. The German Center for Neurodegenerative Diseases (DZNE) in Rostock coordinates it. Data were collected retrospectively, first from AD patients and controls, with MCI patients added from 2013. The database is meant to keep growing, so the numbers below describe the state of March 2016.
Composition
The study sample holds 139 patients with probable AD (NINCDS-ADRDA criteria), 160 with MCI (Petersen criteria) and 194 cognitively healthy controls. Mean age is 73 years in the AD and MCI groups and 69 years in the control group. The paper gives sex per group. Demographic and clinical data come with the images. Neuropsychological scores (CERAD), APOE status, CSF amyloid and tau, and clinical follow-up exist only for subsets; for example, CSF data cover 76 MCI patients and follow-up shows 46 of 106 MCI patients converting to AD.
Acquisition
After quality control there are 493 DTI scans, 512 3D T1-weighted scans and 300 FLAIR scans. They come from 11 centers in Germany, Italy, Ireland, the Netherlands and the United Kingdom, on 13 scanners from GE, Siemens and Philips at 1.5 T or 3 T. DTI protocols differ between scanners, with 6 to 61 gradient directions and mostly b = 1000 s/mm². The data are offered as DICOM and NIfTI, and as NIfTI preprocessed at the coordinating center with FSL and SPM8 (eddy current and motion correction, tensor fitting, registration to a custom template, smoothing).
Known limitations
- Acquisition protocols are not harmonized, which suits multicenter variability studies but adds site effects.
- FLAIR scans and most clinical extras cover only part of the sample.
- Scans that failed quality control were removed from the shared database.
- The neuGRID2 data portfolio describes its copy as 471 DTI and 471 MPRAGE scans, so the hosted version can differ from the paper.
- The paper's Table 3 lists one center's scanner as a "Siemens Achieva", a model name Philips uses, so the split between Siemens and Philips scans is uncertain.
- Access requires registration and a signed data usage agreement whose text is not published.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 493 subjects.
Sex
- Female 247 50%
- Male 246 50%
Condition
Groups can overlap
- Healthy control 194 39%Age mean 69 ± 6
- Mild cognitive impairment 160 32%Age mean 73 ± 7
- Alzheimer's disease 139 28%Age mean 73 ± 8
Section 2.1, Table 1 in Brueggen K et al. 2017, The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment, NeuroImage
Condition by contrast / sequence
ScansReported cross table. A dot marks a cell the source does not give.
| Diffusion-weighted | |
|---|---|
| Healthy control | 194 |
| Mild cognitive impairment | 160 |
| Alzheimer's disease | 139 |
Contrast / sequence by scanner vendor
ScansReported cross table. A dot marks a cell the source does not give.
| GE HealthCare | |
|---|---|
| Diffusion-weighted | 18 |
Contrast / sequence
ScansGroups can overlap
- T1-weighted 512 39%
- Diffusion-weighted 493 38%
- FLAIR 300 23%
Condition by sex
Reported cross table. A dot marks a cell the source does not give.
| Female | Male | |
|---|---|---|
| Healthy control | 99 | 95 |
| Mild cognitive impairment | 69 | 91 |
| Alzheimer's disease | 79 | 60 |
Field strength by contrast / sequence
ScansReported cross table. A dot marks a cell the source does not give.
| Diffusion-weighted | |
|---|---|
| 3 T | 365 |
| 1.5 T | 128 |
Tables 3 and 4 in Brueggen K et al. 2017, The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment, NeuroImage
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Sign a data use agreement, often reviewed by the provider
European DTI Study on Dementia Data Usage Agreement
Open to anyone with a scientific interest after registering and signing a data usage agreement, either on neuGRID or by e-mail to DZNE Rostock. The agreement text itself is not published, so every rule other than the signature is unspecified.
What you can do
- Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Yes
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Brueggen K, Grothe MJ, Dyrba M, et al. The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment. NeuroImage 144(Pt B):305-308 (2017). doi:10.1016/j.neuroimage.2016.03.067
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.