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MRI Brain

Diff5T

Diff5T: Benchmarking human brain diffusion MRI with an extensive 5.0 Tesla k-space and spatial dataset

Brain diffusion MRI with raw multi-channel k-space from healthy young adults, released to benchmark reconstruction, artifact correction, preprocessing, microstructure modelling and tractography at an intermediate field strength, with high-resolution T1w and T2w scans.

Overview

Diff5T is a brain diffusion MRI collection acquired on a 5.0 T scanner, built so that methods for k-space reconstruction, artifact correction, preprocessing, microstructure modelling and tractography can be developed and compared on one benchmark. It was created at the Shenzhen Institutes of Advanced Technology with collaborators and is described in a Scientific Data paper from 2025. Besides reconstructed images it ships the raw multi-channel k-space of the diffusion series.

Composition

The release covers 50 healthy volunteers aged 18 to 38 years with no history of brain disease. Each person has three diffusion series, a T1w scan and a T2w scan. Four kinds of records are provided: raw diffusion k-space with calibration and navigator lines (MAT files), k-space after offline parallel reconstruction, reconstructed images before and after preprocessing, and scanner images converted from DICOM to NIfTI with JSON sidecars. Version 3 of the record added complex-valued noise scans from the diffusion acquisitions. The paper does not report the sex split.

Acquisition

All scans come from a United Imaging uMR Jupiter 5.0 T system with a 48-channel head receive coil. Diffusion imaging used multiband EPI at 1.2 mm isotropic resolution: 90 directions each at b = 1000, 2000 and 3000 s/mm², plus 21 b = 0 volumes, 6 of them with reversed phase encoding, in about 45 minutes. T1w (fast spoiled gradient echo) and T2w (3D fast spin echo) images were acquired at 0.5 mm isotropic resolution with compressed sensing.

Annotations

There are no manual labels. The paper documents its reconstruction and preprocessing pipelines and shows example DTI, NODDI and tractography results for quality checking.

Known limitations

The cohort is small, young and healthy, and all data come from one scanner model at one site. The authors note that their offline reconstruction pipeline is not optimal. The full release is about 21 TB, and files are only shared after an access request for non-commercial research is approved.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 50 subjects.

Age

range 18 to 38

No age bins reported.

Methods, Participants in Wang et al. 2025, Scientific Data

Condition

Groups can overlap

  • Healthy control 50 100%

Methods, Participants in Wang et al. 2025, Scientific Data

Field strength

  • 5 T 50 100%

Methods, Hardware in Wang et al. 2025, Scientific Data

Contrast / sequence

Groups can overlap

  • Diffusion-weighted 50 100%
  • T1-weighted 50 100%
  • T2-weighted 50 100%

Background & Summary in Wang et al. 2025, Scientific Data

Scanner vendor

  • United Imaging 50 100%

Methods, Hardware in Wang et al. 2025, Scientific Data

Country

  • China 50 100%

Methods, Participants in Wang et al. 2025, Scientific Data

Contrast combinations

How many subjects have exactly each set of contrasts.

T1wT2wdwiSubjects with exactly this set
50

Background & Summary in Wang et al. 2025, Scientific Data

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
Application

A research proposal is reviewed and approved

Restricted access on Science Data Bank. The request states a non-commercial research purpose and the commitments listed on the record, including adherence to the Diff5T data usage agreement. The depositor decides whether to grant access.

Access page

Data Usage Agreement (DUA) of Diff5T Dataset

Access is requested on Science Data Bank with a short description of a non-commercial research purpose and explicit commitments to cite the paper, use the data non-commercially, never re-identify participants and follow the agreement. The data may not be passed to any other group, misuse must be reported within 15 days, and publications must cite and acknowledge the Diff5T paper.

Original license text Version read: Text on the Science Data Bank record, dataset version V4, read 2026-10-12 Checked 2026-10-12

What you can do

  • No
  • Not stated
  • Not stated
  • Not stated
  • Conditional

What you can share

  • No
  • Not stated
  • Share trained models Not stated

What you must do

  • Yes
  • Share alike No
  • Yes
  • Conditional
  • Manuscript review No
  • Release code No
  • Return results No
  • Delete after use No

Limits

  • Yes
  • Location limits No

Citation

Wang, S., Yu, S., Cheng, J. et al. Diff5T: Benchmarking human brain diffusion MRI with an extensive 5.0 Tesla k-space and spatial dataset. Scientific Data 12, 1352 (2025). doi:10.1038/s41597-025-05640-2.

Sources

Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.