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MRI Brain

CANDI Share: Schizophrenia Bulletin 2008

Child and Adolescent NeuroDevelopment Initiative Share, Schizophrenia Bulletin 2008 data

Preprocessed structural brain MRI with whole-brain segmentations of children and adolescents with bipolar disorder or schizophrenia spectrum illness and healthy controls, from a study of limbic volumes in early-onset illness. 103 young people: 54 bipolar, 20 schizophrenia spectrum, 29 controls.

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Overview

This collection holds the structural brain MRI behind a 2008 study of limbic volumes in young people with early-onset bipolar disorder or schizophrenia spectrum illness. The Child and Adolescent NeuroDevelopment Initiative (CANDI) released it in 2012 on NITRC as part of its CANDI Share data, with preprocessed images and the matching segmentations. It suits work on pediatric brain segmentation and on comparing psychiatric groups with controls.

Composition

There are 103 participants, each with one MR session:

Group Subjects
Healthy controls 29
Schizophrenia spectrum 20
Bipolar disorder with psychosis 19
Bipolar disorder without psychosis 35

The schizophrenia group includes schizoaffective disorder. The open subject listing on the NITRC image repository gives sex (57 male, 46 female), age in whole years, handedness and diagnostic group for every subject.

Acquisition

All scans were acquired on a 1.5 Tesla GE Signa scanner at the McLean Hospital Brain Imaging Center. Participants were recruited through McLean Hospital, Cambridge Health Alliance and professional and patient advocacy groups. The study protocol included a T1-weighted sagittal scout, an axial proton density and T2-weighted double-echo series and a three-dimensional inversion recovery prepped spoiled gradient coronal series. The release contains one preprocessed anatomical volume per session (labelled anat) in NIfTI format, plus a quality-control snapshot. This index lists it as T1-weighted, assuming it is the inversion recovery series used for the volumetric analysis.

Annotations

Each session has a segmentation label map in NIfTI. In the paper, two raters at the Center for Morphometric Analysis outlined the amygdala, hippocampus, thalamus, caudate, putamen, globus pallidus and nucleus accumbens with the Cardviews software. A sample label map from the release also contains cerebral cortex, white matter and ventricle labels, coded with FreeSurfer-style label numbers.

Known limitations

  • The paper gives an age range of 6 to 17 years, while the repository listing records ages from 4 to 16. The source of the difference is not documented.
  • The repository holds preprocessed images only. The proton density and T2-weighted series from the protocol are not part of the release.
  • The license is shown as Creative Commons "Attribution" without a version number.
  • Small groups from a single site and scanner.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 103 subjects.

Sex

  • Female 46 45%
  • Male 57 55%

gender in NITRC-IR subject listing of project cs_schizbull08 (open, no login), one row per subject

Contrast / sequence

Groups can overlap

  • T1-weighted 103 100%

scans per session in NITRC-IR session listing of project cs_schizbull08 (open, no login)

Field strength

  • 1.5 T 103 100%

Abstract (Methods) in Frazier et al. 2008, Schizophrenia Bulletin

Age

mean 10.8 ± 3.1, median 11, range 4 to 16

0
20
40
60
64
0-910-19

age in NITRC-IR subject listing of project cs_schizbull08 (open, no login), one row per subject

Condition

Groups can overlap

  • Bipolar disorder 54 52%
  • Healthy control 29 28%
    Age mean 10.5 ± 2.9
  • Schizophrenia 20 19%
    Age mean 13.5 ± 2.9

Abstract (Methods), Methods (Subjects) in Frazier et al. 2008, Schizophrenia Bulletin

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
Open download

Download without an account

Access page

NITRC project license "Creative Commons License > Attribution" (version not stated)

NITRC project pages can mark a project with the Creative Commons "Attribution" license without naming a version. The page quotes the Creative Commons description: distribution, remixing and building upon the work are allowed, also commercially, as long as the creators are credited. Questions the description does not address stay open.

Original license text Version read: NITRC project page text, read 2026-10-08 Checked 2026-10-08

What you can do

  • Yes
  • Yes
  • Not stated
  • Yes
  • Not stated

What you can share

  • Yes
  • Not stated
  • Share trained models Not stated

What you must do

  • Yes
  • Share alike No
  • Sign an agreement No
  • Ethics approval No
  • Manuscript review No
  • Release code No
  • Return results No
  • Delete after use No

Limits

  • No re-identification No
  • Location limits No

Citation

Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B, Makris N. Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Schizophrenia Bulletin 34(1):37-46 (2008). doi:10.1093/schbul/sbm120

Sources

Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.