CANDI Share: Schizophrenia Bulletin 2008
Child and Adolescent NeuroDevelopment Initiative Share, Schizophrenia Bulletin 2008 data
Preprocessed 1.5T T1-weighted brain MRI with whole-brain segmentations of 103 children and adolescents: 29 healthy controls, 20 with schizophrenia spectrum illness and 54 with bipolar disorder with or without psychosis.
Overview
This collection holds the structural brain MRI behind a 2008 study of limbic volumes in young people with early-onset bipolar disorder or schizophrenia spectrum illness. The Child and Adolescent NeuroDevelopment Initiative (CANDI) released it in 2012 on NITRC as part of its CANDI Share data, with preprocessed images and the matching segmentations. It suits work on pediatric brain segmentation and on comparing psychiatric groups with controls.
Composition
There are 103 participants, each with one MR session:
| Group | Subjects |
|---|---|
| Healthy controls | 29 |
| Schizophrenia spectrum | 20 |
| Bipolar disorder with psychosis | 19 |
| Bipolar disorder without psychosis | 35 |
The schizophrenia group includes schizoaffective disorder. The open subject listing on the NITRC image repository gives sex (57 male, 46 female), age in whole years, handedness and diagnostic group for every subject.
Acquisition
All scans were acquired on a 1.5 Tesla GE Signa scanner at the McLean Hospital Brain Imaging Center. Participants
were recruited through McLean Hospital, Cambridge Health Alliance and professional and patient advocacy groups. The study
protocol included a T1-weighted sagittal scout, an axial proton density and T2-weighted double-echo series and a
three-dimensional inversion recovery prepped spoiled gradient coronal series. The release contains one preprocessed
anatomical volume per session (labelled anat) in NIfTI format, plus a quality-control snapshot. This index lists
it as T1-weighted, assuming it is the inversion recovery series used for the volumetric analysis.
Annotations
Each session has a segmentation label map in NIfTI. In the paper, two raters at the Center for Morphometric Analysis outlined the amygdala, hippocampus, thalamus, caudate, putamen, globus pallidus and nucleus accumbens with the Cardviews software. A sample label map from the release also contains cerebral cortex, white matter and ventricle labels, coded with FreeSurfer-style label numbers.
Known limitations
- The paper gives an age range of 6 to 17 years, while the repository listing records ages from 4 to 16. The source of the difference is not documented.
- The repository holds preprocessed images only. The proton density and T2-weighted series from the protocol are not part of the release.
- The license is shown as Creative Commons "Attribution" without a version number.
- Small groups from a single site and scanner.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 103 subjects.
Sex
- Male 57 55%
- Female 46 45%
Age
mean 10.8± 3.1 · range 4 to 16Contrast / sequence
subjects, values can overlap
- T1-weighted 103 100%
Condition
subjects, values can overlap
- Bipolar disorder 54 52%
- Healthy control 29 28%
- Schizophrenia 20 19%
Field strength
subjects
- 1.5 T 103 100%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Download without an account
NITRC project license "Creative Commons License > Attribution" (version not stated)
NITRC project pages can mark a project with the Creative Commons "Attribution" license without naming a version. The page quotes the Creative Commons description: distribution, remixing and building upon the work are allowed, also commercially, as long as the creators are credited. Questions the description does not address stay open.
What you can do
- Yes
- Not stated
- Yes
- Not stated
What you can share
- Yes
- Not stated
- Share trained models Not stated
What you must do
- Yes
- Share alike No
- Sign an agreement No
- Ethics approval No
- Manuscript review No
- Release code No
- Return results No
- Delete after use No
Limits
- No re-identification No
- Location limits No
Citation
Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B, Makris N. Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Schizophrenia Bulletin 34(1):37-46 (2008). doi:10.1093/schbul/sbm120
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total Sum of the four disjoint diagnostic groups (35, 19, 20 and 29) | 103 | frazier2008 Abstract (Methods) |
| Subjects | condition=bipolar_disorder Sum of 35 without psychosis and 19 with psychosis | 54 | frazier2008 Abstract (Methods) |
| Subjects | condition=schizophrenia Schizophrenia spectrum (schizophrenia or schizoaffective disorder) | 20 | frazier2008 Abstract (Methods) |
| Subjects | condition=healthy | 29 | frazier2008 Abstract (Methods) |
| Subjects | sex=male | 57 | nitrc-ir-subjects gender |
| Subjects | sex=female | 46 | nitrc-ir-subjects gender |
| Subjects | age=0-9 | 39 | nitrc-ir-subjects age |
| Subjects | age=10-19 | 64 | nitrc-ir-subjects age |
| Subjects | contrast=T1w One anat scan per session | 103 | nitrc-ir-experiments scans per session |
| Subjects | field_strength=1.5 | 103 | frazier2008 Abstract (Methods) |
| Studies | total One MR session per subject | 103 | nitrc-ir-experiments rows |
| Scans | total | 103 | nitrc-ir-experiments scans per session |
| Mean age | total Ages listed in whole years | 10.8 | nitrc-ir-subjects age |
| Age SD | total | 3.1 | nitrc-ir-subjects age |
| Median age | total | 11 | nitrc-ir-subjects age |
| Minimum age | total | 4 | nitrc-ir-subjects age |
| Maximum age | total | 16 | nitrc-ir-subjects age |
| Mean age | condition=schizophrenia | 13.5 | frazier2008 Methods (Subjects) |
| Age SD | condition=schizophrenia | 2.9 | frazier2008 Methods (Subjects) |
| Mean age | condition=healthy | 10.5 | frazier2008 Methods (Subjects) |
| Age SD | condition=healthy | 2.9 | frazier2008 Methods (Subjects) |
Sources
The keys used in the table above.
- frazier2008 Frazier et al. 2008, Schizophrenia Bulletin paper
- nitrc-cs-schizbull08 NITRC project page CANDI Share Schizophrenia Bulletin 2008 website
- nitrc-ir-subjects NITRC-IR subject listing of project cs_schizbull08 (open, no login), one row per subject computed
- nitrc-ir-experiments NITRC-IR session listing of project cs_schizbull08 (open, no login) computed