D-dimer and Cerebral Infarction in ICU Cancer Patients
D-dimer Levels and Cerebral Infarction in Critically Ill Cancer Patients
Brain MRI of adults with cancer in a medical oncology intensive care unit, scanned for suspected acute ischemic stroke, collected to study stroke patterns and D-dimer levels. Images are not shared; a per-patient clinical table is public.
Overview
This entry covers a retrospective brain MRI cohort from the medical oncology intensive care unit of Samsung Medical Center in Seoul. Between March 2010 and February 2014, adult cancer patients who developed acute neurological deficits in the unit had brain MRI because a cerebral infarction was suspected. Two papers by the same group analyse the cohort: one describes the clinical picture and diffusion lesion patterns of stroke in these patients, the other asks whether D-dimer levels help to diagnose infarction or point to a cryptogenic cause. The MRI images are not public. Harvard Dataverse hosts, under CC0 1.0, one spreadsheet with a row per patient.
Composition
Of 2258 patients admitted to the unit in the study period, 88 met the inclusion criteria: 33 with solid tumors and 55 with hematologic malignancies, 51 of them men. Infarction was diagnosed in 43 patients, most often as multiple lesions across arterial territories, and 7 had central nervous system metastases. The age rows in the statistics are counted from the released spreadsheet.
Acquisition
The BMC Cancer paper names two scanners used for brain MRI at the center: a 1.5 T GE Signa with a quadrature head coil (1997 to 2010) and a 3 T Philips Achieva with an eight-channel head coil (2006 to 2014). It does not say which patient was scanned on which system. Infarction was defined by high signal on diffusion-weighted imaging with reduced apparent diffusion coefficient. Vessel imaging (non-contrast or contrast-enhanced MR angiography, or CT angiography) and echocardiography were used to classify stroke etiology, but the papers do not give how many patients had each.
Annotations
Two neurologists and a neuroradiologist read every scan. The spreadsheet records the stroke diagnosis, lesion location, DWI lesion pattern, TOAST stroke mechanism and the main finding in patients without infarction. No image annotations are released.
Known limitations
- MRI images are not shared, and no terms for them are published.
- Single center, retrospective, and limited to patients in whom stroke was suspected.
- The median age computed from the spreadsheet (64) differs from the 63 stated in both papers.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 88 subjects.
Sex
- Female 37 42%
- Male 51 58%
Table 1 in Ryu et al. 2017, BMC Cancer 17:591; Sex in D-dimer levels and ischemic stroke HDN.xlsx (Harvard Dataverse, CC0 1.0), counted per patient row
Condition
Groups can overlap
- Cancer 88 100%
- Ischemic stroke 43 49%
- Brain metastases 7 8%
Table 1, Table 2 in Ryu et al. 2017, BMC Cancer 17:591
Condition by sex
Reported cross table. A dot marks a cell the source does not give.
| Male | |
|---|---|
| Ischemic stroke | 26 |
Table 2 in Ryu et al. 2016, PLOS ONE 11(1):e0146836
Age
mean 59.7, median 64, range 25 to 78
Age in D-dimer levels and ischemic stroke HDN.xlsx (Harvard Dataverse, CC0 1.0), counted per patient row
Age by sex
Reported cross table. Missing cells were not published (fewer than 10 or not reported).
- 1270-79n/a
- 1460-6921
- n/a50-5911
Age and Sex in D-dimer levels and ischemic stroke HDN.xlsx (Harvard Dataverse, CC0 1.0), counted per patient row
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
The data are not available outside the institution or study that holds them
The Harvard Dataverse release holds no MRI images. It contains one spreadsheet with per-patient clinical, laboratory and MRI reading data (stroke diagnosis, lesion location, DWI pattern, stroke mechanism), openly downloadable under CC0 1.0.
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
No license or data use terms are stated for the MRI images. The CC0 1.0 waiver on the Dataverse record covers only the released spreadsheet.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Ryu, J.-A., Bang, O. Y., & Lee, G.-H. (2017). D-dimer levels and cerebral infarction in critically ill cancer patients. BMC Cancer, 17, 591. https://doi.org/10.1186/s12885-017-3588-7
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.
- Harvard Dataverse record, D-dimer Levels and Cerebral Infarction in Critically Ill Cancer Patients, version 1.0 website
- Ryu et al. 2017, BMC Cancer 17:591 paper
- Ryu et al. 2016, PLOS ONE 11(1):e0146836 paper
- D-dimer levels and ischemic stroke HDN.xlsx (Harvard Dataverse, CC0 1.0), counted per patient row computed