Cerebellar ataxia FDG PET (Asan)
Different subregional metabolism patterns in patients with cerebellar ataxia by 18F-fluorodeoxyglucose positron emission tomography
Retrospective brain FDG PET of patients with cerebellar-type multiple system atrophy and spinocerebellar ataxia types 2 and 6, compared with crossed cerebellar diaschisis and healthy controls to map cerebellar subregional metabolism. 171 subjects from Seoul. Images on request.
Overview
This retrospective cohort comes from Asan Medical Center in Seoul, Korea. The authors used brain FDG PET to ask whether different cerebellar diseases leave different metabolic footprints across subregions of the cerebellum. Patients with cerebellar-type multiple system atrophy (MSA-C) and with genetically confirmed spinocerebellar ataxia types 2 and 6 were compared with two reference groups: patients whose cerebellar hypometabolism came from crossed cerebellar diaschisis after a frontal brain tumor, and healthy controls. The images are not public. The data availability statement offers the analysis data on request through a data monitoring committee at the hospital, and the PLOS figshare record contains only the three supplementary figures.
Composition
171 subjects in five groups: 44 MSA-C, 9 SCA type 2, 14 SCA type 6, 15 crossed cerebellar diaschisis and 89 healthy controls. Table 1 gives sex and mean age per group; across all groups there are 98 men and 73 women. The healthy controls, aged 17 to 85, were drawn from the hospital's normal FDG PET pool. The SCA cases cover every SCA diagnosis made between March 2006 and September 2013; the MSA-C patients were scanned between March 2006 and December 2010 and followed for at least two years. Clinical features, UPDRS III scores and CAG repeat counts come from medical records.
Acquisition
After at least six hours of fasting, 159 subjects were scanned on a CTI-Siemens ECAT HR+ (370 MBq FDG, 15-minute emission scan starting 40 minutes after injection, germanium-68 transmission for attenuation correction) and 12 on a GE Discovery 690 PET/CT with CT-based attenuation correction. Images were reconstructed with OSEM.
Annotations
A nuclear medicine physician drew 8 mm circular volumes of interest for 13 cerebellar subregions on a study-specific template built from spatially normalized control scans. Uptake was normalized to the occipital cortex, chosen by a voxelwise search for the least affected region.
Known limitations
- Images and clinical data are not released; access depends on a request to the hospital.
- Single centre with two scanner types.
- MSA-C diagnoses are clinical, without postmortem confirmation.
- Small SCA groups.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 171 subjects.
PET tracer
- [18F]FDG 171 100%
Materials and methods (18F-FDG PET image acquisition) in Oh et al. 2017, PLoS ONE 12(3), e0173275
Scanner vendor
- Siemens Healthineers 159 93%
- GE HealthCare 12 7%
Materials and methods (18F-FDG PET image acquisition) in Oh et al. 2017, PLoS ONE 12(3), e0173275
Country
- South Korea 171 100%
Affiliations; Materials and methods (Subjects) in Oh et al. 2017, PLoS ONE 12(3), e0173275
Modality
- PET 171 100%
Materials and methods (18F-FDG PET image acquisition) in Oh et al. 2017, PLoS ONE 12(3), e0173275
Condition
Groups can overlap
- Healthy control 89 52%Age mean 49.9 ± 14, range 17 to 85
- Multiple system atrophy, cerebellar type 44 26%Age mean 55.9 ± 7
- Brain tumor 15 9%Age mean 49.3 ± 11.3
- Spinocerebellar ataxia type 6 14 8%Age mean 58.3 ± 9.4
- Spinocerebellar ataxia type 2 9 5%Age mean 38.2 ± 12.7
Table 1; Materials and methods (Subjects), Table 1, Materials and methods (Subjects) in Oh et al. 2017, PLoS ONE 12(3), e0173275
Condition by sex
Reported cross table. A dot marks a cell the source does not give.
| Female | Male | |
|---|---|---|
| Healthy control | 34 | 55 |
| Multiple system atrophy, cerebellar type | 20 | 24 |
| Brain tumor | 8 | 7 |
| Spinocerebellar ataxia type 6 | 6 | 8 |
| Spinocerebellar ataxia type 2 | 5 | 4 |
Table 1 in Oh et al. 2017, PLoS ONE 12(3), e0173275
License and access
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Ask the authors or the data holder. No published process or terms, and access is at their discretion
The paper's data availability statement says ethical and legal restrictions prevent public release and that the analysis data are available on request from the Correlative Neuroimaging Lab data monitoring committee at Asan Medical Center. The PLOS figshare record holds only the three supplementary figures.
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
No license or data use terms for the images are published. The CC BY 4.0 license of the article and its figshare record covers the text and figures only.
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What you must do
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Limits
- No re-identification Not stated
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Citation
Oh M, Kim JS, Oh JS, Lee CS, Chung SJ. Different subregional metabolism patterns in patients with cerebellar ataxia by 18F-fluorodeoxyglucose positron emission tomography. PLoS ONE 12(3), e0173275 (2017). doi:10.1371/journal.pone.0173275
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.