ADNI-D
Alzheimer's Disease Neuroimaging Initiative Depression Project (ADNI-D)
US two-site ADNI companion study of adults aged 65 and over with current major depression, with 3T MRI (T1w, FLAIR, T2* GRE, DTI, ASL, fMRI), florbetapir amyloid PET and repeated cognitive testing, shared through the LONI IDA after an approved application.
Overview
The ADNI Depression Project (ADNI-D) is a companion study to the Alzheimer's Disease Neuroimaging Initiative that asks why older adults with major depression show cognitive impairment and faster cognitive decline. ADNI itself excluded people with major depression, so ADNI-D enrolled them separately and imaged them with ADNI methods, so that brain atrophy, white matter lesions, cerebral blood flow and amyloid burden can be compared with non-depressed ADNI participants. The project started in 2013 under R. Scott Mackin at UCSF and is funded by NIMH with a contribution from Eli Lilly. Data are distributed by LONI through a separate ADNI-D database on the Image and Data Archive.
Composition
The protocol planned 120 participants aged 65 or older with a current DSM-IV diagnosis of unipolar major depression without psychosis, an episode of at least six weeks and a Hamilton depression score of 15 or more, while dementia was excluded. Non-depressed comparison data are taken from ADNI rather than collected in ADNI-D. The first main paper analysed 119 depressed participants with a mean age of 70.9 years (range 65 to 91), 80 of them women; 39 met ADNI criteria for mild cognitive impairment.
Acquisition
Participants were recruited through the psychiatry departments of UCSF and the University of Pittsburgh and scanned at the matching ADNI sites, which had taken part in ADNI-2. The baseline visit includes a 3T MRI with an accelerated 3D T1-weighted scan, axial FLAIR, T2* gradient echo, DTI, arterial spin labeling, functional MRI, a fat-saturated T2 fast spin echo and a field map, plus florbetapir amyloid PET acquired as four 5-minute frames from 50 minutes after injection. Clinical, cognitive and mood assessments, blood for APOE genotyping, GWAS and plasma biomarkers are collected at baseline and again after about 30 months, with telephone checks at 12 and 24 months.
Annotations
There are no image labels. Each participant has a SCID diagnosis, a depression and treatment history, depression rating scales and the ADNI cognitive battery. Radiologists give a local clinical read of every MRI.
Known limitations
The cohort is small and comes from two sites, while ADNI comparison participants were scanned at many sites and scanner types. The total number enrolled and imaged is not stated in the public sources found. The protocol schedules MRI and PET at baseline only, so imaging is cross-sectional.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 119 subjects.
Sex
- Female 80 100%
Covers 80 of 119 subjects.
Age
mean 70.9± 5.3 · range 65 to 91No age bins reported.
Modality
subjects
- PET 119 100%
PET tracer
subjects
- [18F]florbetapir 119 100%
Condition
subjects, values can overlap
- Major depressive disorder 119 100%
- Mild cognitive impairment 39 33%
Country
subjects
- United States 119 100%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
A research proposal is reviewed and approved
ADNI Depression Project Data Use Agreement
Access for scientific investigation, teaching or planning clinical research after an online application. No redistribution of the data, "for the ADNI Depression Project" in every manuscript author line and a review of every manuscript by the ADNI Depression Data and Publications Committee before journal submission.
What you can do
- Not stated
- Not stated
- Not stated
- Not stated
- Conditional
What you can share
- No
- Not stated
- Share trained models Not stated
What you must do
- Yes
- Share alike No
- Yes
- Conditional
- Yes
- Release code No
- No
- Delete after use No
Limits
- Yes
- No
Citation
Add "for the ADNI Depression Project*" to the author line and use the methods and funding text given in the ADNI Depression Data Use Agreement. Cohort reference: Mackin RS, et al. Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project. Biol Psychiatry 89(8):757-765 (2021). doi:10.1016/j.biopsych.2020.06.017
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total participants with late-life major depression analysed in the paper; the total enrolment in ADNI-D is not reported. The 119 non-depressed comparison participants come from ADNI, not ADNI-D | 119 | mackin2021 Table 1 |
| Subjects | condition=depression current DSM-IV major depressive disorder with HDRS-17 of 15 or more | 119 | mackin2021 Table 1 |
| Subjects | condition=mci met ADNI criteria for MCI (33%) | 39 | mackin2021 Table 1 |
| Subjects | sex=female | 80 | mackin2021 Table 1 |
| Subjects | modality=PT florbetapir PET coregistered to a structural MRI | 119 | mackin2021 Methods (Amyloid burden) |
| Subjects | tracer=florbetapir | 119 | mackin2021 Methods (Amyloid burden) |
| Subjects | country=US UCSF and University of Pittsburgh | 119 | mackin2021 Methods (Procedures) |
| Mean age | total | 70.9 | mackin2021 Table 1 |
| Age SD | total | 5.3 | mackin2021 Table 1 |
| Minimum age | total | 65 | mackin2021 Table 1 |
| Maximum age | total | 91 | mackin2021 Table 1 |
Sources
The keys used in the table above.
- mackin2021 Mackin RS et al. 2021, Late-life depression is associated with reduced cortical amyloid burden, Biological Psychiatry (author manuscript PMC10165941) paper
- adnid-protocol-2014 ADNI-D study protocol, 19 November 2014 website
- adnid-procedures-manual-2017 ADNI-D procedures manual, 15 February 2017 website
- adni-related-studies ADNI website, Related & Collaborative Studies (ADNI-D section) website