ABVIB
Aging Brain - Vasculature, Ischemia, and Behavior Study (ABVIB)
Serial brain MRI, amyloid PET in a subset, neuropsychological tests and vascular risk measures of older adults, collected to study how cardiovascular risk and cerebrovascular disease affect brain structure and cognition, alone or with Alzheimer disease. Access by data use application.
Overview
The Aging Brain: Vasculature, Ischemia, and Behavior Study (ABVIB) is a program project funded by the National Institute on Aging (P01 AG12435) and led by Helena C. Chui at the University of Southern California. It started in 1994 and asks how cardiovascular risk factors and cerebrovascular disease shape brain structure and cognition in older adults, on their own and together with Alzheimer disease. Its database is held on the LONI Image and Data Archive and is opened to researchers who submit a data use application.
Composition
According to the data use agreement, the database holds data from a second study cohort enrolled from 2008 to 2013. Measures include laboratory tests of cardiovascular risk, carotid intima media thickness, retinal vessel measures, serial MRI and neuropsychological testing, with amyloid PET for part of the participants. The study does not publish how many participants, visits or scans the shared database contains, so no counts are listed here.
Acquisition
The program's PiB substudy (Marchant et al. 2013, 61 participants) describes the imaging used in that analysis: most participants had T1-weighted MPRAGE and FLAIR on a Siemens 3 T Trio with an 8-channel head coil, a few were scanned on a Siemens 4 T MedSpec or a GE 1.5 T Signa, and amyloid PET used [11C]PiB with 90 minutes of dynamic acquisition on a high-resolution Siemens ECAT EXACT scanner. Whether the shared database follows the same protocol throughout is not stated.
Known limitations
- The program set out to recruit people with substantial vascular risk factors and vascular brain injury, so the cohort is not representative of the general older population.
- Scanners and field strengths differ between participants.
- Amyloid PET covers only a subset of participants.
- No public description of the released database exists beyond the data use agreement; contents must be checked after access is granted.
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
A research proposal is reviewed and approved
Aging Brain - Vasculature, Ischemia, and Behavior Study (ABVIB) Data Use Agreement
Access for scientific investigation, teaching or planning clinical research after an online data use application on the LONI IDA. No redistribution of the data, the ABVIB phrase on every manuscript by-line, set methods and funding text, and a review of every manuscript by the ABVIB Data and Publications Committee before journal submission.
What you can do
- Not stated
- Not stated
- Not stated
- Not stated
- Conditional
What you can share
- No
- Not stated
- Share trained models Not stated
What you must do
- Yes
- Share alike No
- Yes
- Conditional
- Yes
- Release code No
- No
- Delete after use No
Limits
- Yes
- No
Citation
No dataset paper. The data use agreement requires "for the Aging Brain: Vasculature, Ischemia, and Behavior Study*" on the manuscript by-line with the listed key investigators, methods text naming the ABVIB database, and the funding acknowledgement "Data collection and sharing for this project was funded by the National Institutes on Aging (NIA) P01 AG12435."
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.
- LONI IDA, ABVIB Data Use Agreement (data use application page) website
- Marchant et al. 2013, The aging brain and cognition: contribution of vascular injury and Abeta to mild cognitive dysfunction, JAMA Neurology (PMC3771392) paper
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