ABIDE II
Autism Brain Imaging Data Exchange II
Resting-state fMRI and T1-weighted MRI, with diffusion MRI for six collections, plus phenotypic data for 1,114 people (521 with autism spectrum disorder, 593 controls, ages 5 to 64) from 19 collections in the US and Europe.
Overview
ABIDE II is the second collection of the Autism Brain Imaging Data Exchange. It was set up with NIMH funding to add a larger and more deeply phenotyped sample to ABIDE I, with a focus on measures of core autism symptoms and co-occurring conditions. The data were released through the 1000 Functional Connectomes Project / INDI in June 2016, with release updates in September 2016 and March 2017.
Composition
The ABIDE II page lists 1,114 datasets from 521 people with autism spectrum disorder and 593 controls, aged 5 to 64 years, across 19 collections. Ten institutions also contributed to ABIDE I and seven are new. The data descriptor covers the 17 collections received by June 2016 (1,044 datasets, median age 11.7 years). Two further longitudinal collections hold a second scan, taken one to four years later, for 38 people whose first scan is in ABIDE I. Phenotypic files give diagnosis, age and sex for everyone, plus IQ, handedness and, for many collections, ADOS, ADI-R, SRS, comorbid psychiatric diagnoses and medication.
Acquisition
Every person has at least one T1-weighted anatomical scan and a resting-state fMRI run, except one person in the IP_1 collection who has only the anatomical scan. Six collections also share diffusion MRI, and one adds FLAIR. All collections used 3 T Siemens, Philips or GE scanners, except IP_1 at 1.5 T. Resting-state runs last five to eight minutes, and eye instructions differ between sites. Faces and ears were removed from high-resolution images before release.
Annotations
There are no image labels. Diagnoses come from each site's own assessment, mostly clinical judgment combined with ADOS and ADI-R. Quality metrics from the Preprocessed Connectome Project protocol (SNR, CNR, framewise displacement and others) are released for the scans.
Known limitations
- Collections were acquired for separate studies, so inclusion criteria, protocols and age ranges differ by site and site effects are large.
- Data were shared regardless of quality, including scans with heavy motion.
- Females make up 15% of the autism group and 31% of the controls in the paper's sample.
- Comparisons with ABIDE I need care: some collections continue ABIDE I protocols, others are independent.
- Per-modality counts are only published for the 17 collections in the paper.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 1,114 subjects.
Contrast / sequence
subjects, values can overlap
- T1-weighted 1,044 94%
- BOLD fMRI 1,043 94%
- Diffusion-weighted 284 25%
Condition
subjects, values can overlap
- Healthy control 593 53%
- Autism spectrum disorder 521 47%
Field strength
subjects
- 1.5 T 56 5%
Country
subjects
- France 56 5%
- Netherlands 54 5%
- Ireland 42 4%
- Switzerland 37 3%
- Belgium 28 3%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Create an account and accept terms online
Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
Older version of CC BY-NC-SA. Non-commercial use only, with credit. Anything you share that is built on the data must use the same license.
The INDI data access policy grants registered users unrestricted use of INDI datasets for non-commercial purposes. The ABIDE II page source carries the same usage agreement as ABIDE I, naming CC BY-NC-SA 3.0, but in a section that is not displayed. Users are asked to acknowledge the ABIDE II funding (NIMH 5R21MH107045).
What you can do
- No
- Conditional
- Yes
- Yes
What you can share
- Conditional
- Conditional
- Conditional
What you must do
- Yes
- Yes
- No
- No
- Manuscript review No
- Release code No
- Return results No
- Delete after use No
Limits
- No
- Location limits No
Citation
Di Martino A, O'Connor D, Chen B, et al. Enhancing studies of the connectome in autism using the autism brain imaging data exchange II. Scientific Data 4:170010 (2017). doi:10.1038/sdata.2017.10
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total 1114 datasets in 19 cross-sectional collections; the paper describes 1,044 from the 17 collections received by June 2016 | 1,114 | indi-abide2 |
| Subjects | condition=autism | 521 | indi-abide2 |
| Subjects | condition=healthy controls | 593 | indi-abide2 |
| Subjects | contrast=T1w high-resolution MRI, 487 ASD + 557 controls, 17 collections in the paper | 1,044 | dimartino2017 Table 1 |
| Subjects | contrast=bold every individual except one in IP_1; Table 1 rows give 487 ASD + 556 controls, its printed control total is 523 | 1,043 | dimartino2017 Data Records (MRI data) |
| Subjects | contrast=dwi 155 ASD + 129 controls in six collections | 284 | dimartino2017 Table 1 |
| Subjects | condition=autism;contrast=T1w | 487 | dimartino2017 Table 1 |
| Subjects | condition=healthy;contrast=T1w | 557 | dimartino2017 Table 1 |
| Subjects | condition=autism;contrast=bold | 487 | dimartino2017 Table 1 |
| Subjects | condition=autism;contrast=dwi | 155 | dimartino2017 Table 1 |
| Subjects | condition=healthy;contrast=dwi | 129 | dimartino2017 Table 1 |
| Subjects | field_strength=1.5 IP_1 is the only 1.5 T collection, 22 ASD + 34 controls with high-resolution MRI | 56 | dimartino2017 Table 1 |
| Subjects | country=NL Erasmus University Medical Center Rotterdam | 54 | indi-abide2 EMC_1 profile |
| Subjects | country=CH ETH Zurich | 37 | indi-abide2 ETH_1 profile |
| Subjects | country=FR Institut Pasteur and Robert Debre Hospital | 56 | indi-abide2 IP_1 profile |
| Subjects | country=BE Katholieke Universiteit Leuven | 28 | indi-abide2 KUL_3 profile |
| Subjects | country=IE Trinity Centre for Health Sciences | 42 | indi-abide2 TCD_1 profile |
| Median age | total median across the 17 collections in the paper | 11.7 | dimartino2017 Figure 1c |
| Minimum age | total | 5 | indi-abide2 |
| Maximum age | total | 64 | indi-abide2 |
Sources
The keys used in the table above.
- indi-abide2 ABIDE II page, FCP/INDI (summary and per-collection profiles) website
- dimartino2017 Di Martino et al. 2017, Scientific Data paper