GROUP Maastricht MRI
Genetic Risk and Outcome of Psychosis (GROUP) MRI study, Maastricht site
Structural and diffusion brain MRI of patients with non-affective psychosis, their unaffected siblings and healthy controls, from a Dutch study of genetic risk and outcome of psychosis. 89 patients, 95 siblings and 87 controls from the Maastricht site. Shared only on request.
Overview
GROUP (Genetic Risk and Outcome of Psychosis) is a Dutch longitudinal cohort run by the psychiatry departments of Amsterdam, Groningen, Maastricht and Utrecht. At baseline it enrolled 1120 patients with non-affective psychosis, 1057 of their siblings, 919 parents and 590 healthy controls. The Maastricht site added a longitudinal brain MRI study to this cohort. This entry covers that MRI sample. It was later pooled into the EU PSYSCAN project as one of its legacy datasets.
Composition
Frissen et al. (2017) describe the baseline MRI sample as 89 patients with a non-affective psychotic disorder, 95 siblings without a lifetime psychotic disorder and 87 controls with no first-degree relative with psychosis. Patients were aged 16 to 50 at inclusion. Several families contributed more than one member, so siblings and patients are partly related. Mean age at scan was 28.1 years in patients, 29.5 in siblings and 30.8 in controls. Men made up 67% of patients, 52% of siblings and 38% of controls. An earlier paper on the same study (Habets et al. 2011) reports 88 patients, 98 siblings and 87 controls. Morgan et al. (2019) analysed a subset of 83 patients and 68 controls with T1-weighted and diffusion data.
Acquisition
All scans come from one 3T Siemens scanner in Maastricht. The T1-weighted sequence changed during data collection after a scanner update: earlier participants had an MDEFT scan (176 slices) and later ones an ADNI MPRAGE (192 slices), both at 1 mm isotropic resolution. Diffusion MRI was also acquired, but its protocol is not described in the open sources. Clinical data include DSM-IV diagnoses from the CASH interview, PANSS symptom scores, cannabis use, childhood trauma and childhood urbanicity.
Annotations
No image annotations. Labels are group (patient, sibling, control), family membership and clinical scores.
Known limitations
- Not public. The only access route is contacting the authors at Maastricht University Medical Centre, and no terms are published.
- Two different T1-weighted sequences, so analyses need to adjust for sequence.
- Reported sample sizes differ slightly between papers, and the number of participants with diffusion data is known only for the Morgan et al. subset.
- Morgan et al. note that many Maastricht patients had low symptom scores, and that image quality was lower than in the other datasets they used.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 271 subjects.
Contrast / sequence
Groups can overlap
- T1-weighted 271 100%
- Diffusion-weighted 151 56%
Methods: MRI acquisition and processing in Frissen et al. 2017, PLOS ONE (PMC5207533); PARC500_FA.dat (one row per subject) in Morgan et al. 2019 Figshare deposit Data_MS_SZ.zip (CC BY 4.0), Maastricht_GROUP folder, counted per subject row
Scanner vendor
- Siemens Healthineers 271 100%
Methods: MRI acquisition and processing in Frissen et al. 2017, PLOS ONE (PMC5207533)
Condition
Groups can overlap
- Psychotic disorder 89 33%
- Healthy control 87 32%
Table 1 in Frissen et al. 2017, PLOS ONE (PMC5207533)
Field strength
- 3 T 271 100%
Methods: MRI acquisition and processing in Frissen et al. 2017, PLOS ONE (PMC5207533)
Condition by sex
Reported cross table. A dot marks a cell the source does not give.
| Male | |
|---|---|
| Psychotic disorder | 60 |
| Healthy control | 33 |
Table 1 in Frissen et al. 2017, PLOS ONE (PMC5207533)
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Ask the authors or the data holder. No published process or terms, and access is at their discretion
The data availability statement of Frissen et al. (2017) says the data are baseline measures of the Maastricht GROUP MRI study and gives a postal address and phone number at Maastricht University Medical Centre for contacting the authors. The cohort website named in GROUP papers (group-project.nl) is now a parked domain. Morgan et al. (2019) used the data as a PSYSCAN legacy dataset and published only derived regional measures.
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
Neither the Frissen et al. (2017) data availability statement nor the GROUP cohort paper (Korver et al. 2012) states a license or data use terms for the images.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Korver N, Quee PJ, Boos HB, Simons CJ, de Haan L, GROUP investigators. Genetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods. International Journal of Methods in Psychiatric Research 21(3):205-221 (2012). doi:10.1002/mpr.1352
Sources
Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.
- Frissen et al. 2017, PLOS ONE (PMC5207533) paper
- Habets et al. 2011, Biological Psychiatry (PubMed abstract, PMID 20951979) paper
- Korver et al. 2012, International Journal of Methods in Psychiatric Research (PMC6878383) paper
- Morgan et al. 2019, PNAS (PMC6511038) paper
- Morgan et al. 2019 Figshare deposit Data_MS_SZ.zip (CC BY 4.0), Maastricht_GROUP folder, counted per subject row computed