GROUP Maastricht MRI
Genetic Risk and Outcome of Psychosis (GROUP) MRI study, Maastricht site
3T brain MRI (T1-weighted, diffusion) from the Maastricht site of the Dutch GROUP psychosis cohort: 89 patients with non-affective psychotic disorder, 95 unaffected siblings and 87 controls. A PSYSCAN legacy dataset, shared only on request.
Overview
GROUP (Genetic Risk and Outcome of Psychosis) is a Dutch longitudinal cohort run by the psychiatry departments of Amsterdam, Groningen, Maastricht and Utrecht. At baseline it enrolled 1120 patients with non-affective psychosis, 1057 of their siblings, 919 parents and 590 healthy controls. The Maastricht site added a longitudinal brain MRI study to this cohort. This entry covers that MRI sample. It was later pooled into the EU PSYSCAN project as one of its legacy datasets.
Composition
Frissen et al. (2017) describe the baseline MRI sample as 89 patients with a non-affective psychotic disorder, 95 siblings without a lifetime psychotic disorder and 87 controls with no first-degree relative with psychosis. Patients were aged 16 to 50 at inclusion. Several families contributed more than one member, so siblings and patients are partly related. Mean age at scan was 28.1 years in patients, 29.5 in siblings and 30.8 in controls. Men made up 67% of patients, 52% of siblings and 38% of controls. An earlier paper on the same study (Habets et al. 2011) reports 88 patients, 98 siblings and 87 controls. Morgan et al. (2019) analysed a subset of 83 patients and 68 controls with T1-weighted and diffusion data.
Acquisition
All scans come from one 3T Siemens scanner in Maastricht. The T1-weighted sequence changed during data collection after a scanner update: earlier participants had an MDEFT scan (176 slices) and later ones an ADNI MPRAGE (192 slices), both at 1 mm isotropic resolution. Diffusion MRI was also acquired, but its protocol is not described in the open sources. Clinical data include DSM-IV diagnoses from the CASH interview, PANSS symptom scores, cannabis use, childhood trauma and childhood urbanicity.
Annotations
No image annotations. Labels are group (patient, sibling, control), family membership and clinical scores.
Known limitations
- Not public. The only access route is contacting the authors at Maastricht University Medical Centre, and no terms are published.
- Two different T1-weighted sequences, so analyses need to adjust for sequence.
- Reported sample sizes differ slightly between papers, and the number of participants with diffusion data is known only for the Morgan et al. subset.
- Morgan et al. note that many Maastricht patients had low symptom scores, and that image quality was lower than in the other datasets they used.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 271 subjects.
Sex
- Male 142 100%
Covers 142 of 271 subjects.
Modality
subjects
- MRI 271 100%
Contrast / sequence
subjects, values can overlap
- T1-weighted 271 100%
- Diffusion-weighted 151 56%
Condition
subjects, values can overlap
- Psychotic disorder 89 33%
- Healthy control 87 32%
Scanner vendor
subjects
- Siemens Healthineers 271 100%
Field strength
subjects
- 3 T 271 100%
Country
subjects
- Netherlands 271 100%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Ask the authors or the data holder. No published process or terms, and access is at their discretion
The data availability statement of Frissen et al. (2017) says the data are baseline measures of the Maastricht GROUP MRI study and gives a postal address and phone number at Maastricht University Medical Centre for contacting the authors. The cohort website named in GROUP papers (group-project.nl) is now a parked domain. Morgan et al. (2019) used the data as a PSYSCAN legacy dataset and published only derived regional measures.
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
Neither the Frissen et al. (2017) data availability statement nor the GROUP cohort paper (Korver et al. 2012) states a license or data use terms for the images.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Korver N, Quee PJ, Boos HB, Simons CJ, de Haan L, GROUP investigators. Genetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods. International Journal of Methods in Psychiatric Research 21(3):205-221 (2012). doi:10.1002/mpr.1352
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total 89 patients, 95 siblings and 87 controls at baseline; the three groups are disjoint. Habets et al. (2011) report 88 patients, 98 siblings and 87 controls | 271 | frissen2017 Methods: Participants |
| Subjects | modality=MR | 271 | frissen2017 Methods: Participants |
| Subjects | contrast=T1w MDEFT or MPRAGE, 1 mm isotropic; the sequence changed after a scanner update during data collection | 271 | frissen2017 Methods: MRI acquisition and processing |
| Subjects | contrast=dwi fractional anisotropy from diffusion MRI for the 151 participants (83 cases, 68 controls) analysed by Morgan et al. (2019); diffusion data for the full sample are not reported | 151 | morgan2019-figshare PARC500_FA.dat (one row per subject) |
| Subjects | condition=psychotic_disorder non-affective psychotic disorder (DSM-IV, CASH interview) | 89 | frissen2017 Table 1 |
| Subjects | condition=healthy controls without a first-degree relative with psychotic disorder; the 95 unaffected siblings of patients are not counted here | 87 | frissen2017 Table 1 |
| Subjects | sex=male 60 patients, 49 siblings and 33 controls; sum of disjoint groups | 142 | frissen2017 Table 1 |
| Subjects | condition=psychotic_disorder;sex=male | 60 | frissen2017 Table 1 |
| Subjects | condition=healthy;sex=male | 33 | frissen2017 Table 1 |
| Subjects | field_strength=3 | 271 | frissen2017 Methods: MRI acquisition and processing |
| Subjects | vendor=siemens | 271 | frissen2017 Methods: MRI acquisition and processing |
| Subjects | country=NL | 271 | frissen2017 Methods: Participants |
Sources
The keys used in the table above.
- frissen2017 Frissen et al. 2017, PLOS ONE (PMC5207533) paper
- habets2011 Habets et al. 2011, Biological Psychiatry (PubMed abstract, PMID 20951979) paper
- korver2012 Korver et al. 2012, International Journal of Methods in Psychiatric Research (PMC6878383) paper
- morgan2019 Morgan et al. 2019, PNAS (PMC6511038) paper
- morgan2019-figshare Morgan et al. 2019 Figshare deposit Data_MS_SZ.zip (CC BY 4.0), Maastricht_GROUP folder, counted per subject row computed