Cambridge Foetal Testosterone (CAM-FT) study, MRI cohort
Cambridge Foetal Testosterone longitudinal study, structural MRI cohort of 8 to 11 year old boys
3 T T1-weighted brain MRI of 28 typically developing boys aged 8 to 11 from Cambridgeshire whose foetal testosterone was measured in amniotic fluid at amniocentesis, used to relate prenatal testosterone to regional grey matter volume. Not publicly shared.
Overview
The Cambridge Foetal Testosterone (CAM-FT) study at the Autism Research Centre, University of Cambridge, follows children whose mothers had amniocentesis during pregnancy, so that hormone levels measured in the amniotic fluid can be related to the child's later behaviour, cognition and brain. Its structural MRI cohort of school-age boys was used to show that higher foetal testosterone goes with more grey matter in some sexually dimorphic regions and less in others. The images are not public.
Composition
28 typically developing boys, mean age 9.5 years (SD 0.92, range 8 to 11), one T1-weighted scan each. 22 of the 28 were right-handed. Their mothers had amniocentesis in Cambridgeshire between 1996 and 1999; records were screened and pregnancies with chromosomal abnormalities, twins, termination or miscarriage, missing records or clinical advice against contact were excluded, as were children with developmental abnormalities after birth. Foetal testosterone was measured by radioimmunoassay in amniotic fluid taken at 13 to 20 weeks of gestation (mean 0.79 nmol/l, range 0.25 to 1.70). The sampling week is missing for 7 boys.
Acquisition
All scans were acquired at the Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge, on a Siemens Tim Trio 3 T scanner with a 3D MP-RAGE sequence at 1 mm isotropic resolution (TR 2300 ms, TE 2.98 ms).
Annotations
There are no manual labels. Grey matter, white matter and CSF were segmented with SPM8 and age-specific tissue priors, and grey matter maps were normalised with DARTEL for voxel-based morphometry. The per-child foetal testosterone value is the target variable.
Known limitations
- No public access route, license or data use terms.
- Small sample of boys only, so sex differences cannot be studied within the cohort.
- The comparison of boys and girls in the paper used a separate public cohort, not CAM-FT scans.
Cohort
Aggregate numbers from the sources below. Bars are relative to the 28 subjects.
Sex
- Male 28 100%
Age
mean 9.5± 0.92 · range 8 to 11No age bins reported.
Contrast / sequence
subjects, values can overlap
- T1-weighted 28 100%
Condition
subjects, values can overlap
- Healthy control 28 100%
Scanner vendor
subjects
- Siemens Healthineers 28 100%
Field strength
subjects
- 3 T 28 100%
Country
subjects
- United Kingdom 28 100%
License and access
Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer
Ask the authors or the data holder. No published process or terms, and access is at their discretion
Neither the paper nor the Autism Research Centre project page offers access to the images or states how to request them. Any request goes to the authors.
No published license or data use terms
The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.
The paper and the project page publish no license or data use terms for the MRI data.
What you can do
- Commercial use Not stated
- Not stated
- Train ML models Not stated
- Create derived data Not stated
- Publish results Not stated
What you can share
- Share the data Not stated
- Share derived data Not stated
- Share trained models Not stated
What you must do
- Cite or credit Not stated
- Share alike Not stated
- Sign an agreement Not stated
- Ethics approval Not stated
- Manuscript review Not stated
- Release code Not stated
- Return results Not stated
- Delete after use Not stated
Limits
- No re-identification Not stated
- Location limits Not stated
Citation
Lombardo MV, Ashwin E, Auyeung B, Chakrabarti B, Taylor K, Hackett G, Bullmore ET, Baron-Cohen S. Fetal testosterone influences sexually dimorphic gray matter in the human brain. J Neurosci 32(2), 674-680 (2012). doi:10.1523/JNEUROSCI.4389-11.2012
All numbers
Every number on this page, as stored in stats.csv, with its source.
| Measure | Breakdown | Value | Source |
|---|---|---|---|
| Subjects | total typically developing boys with foetal testosterone from amniocentesis | 28 | lombardo2012 Materials and Methods, Participants |
| Subjects | sex=male | 28 | lombardo2012 Materials and Methods, Participants |
| Subjects | condition=healthy typically developing; children with postnatal developmental abnormalities were excluded | 28 | lombardo2012 Materials and Methods, Participants |
| Subjects | contrast=T1w 3D MP-RAGE | 28 | lombardo2012 Materials and Methods, MRI Acquisition and Image Processing |
| Subjects | field_strength=3 Siemens Tim Trio | 28 | lombardo2012 Materials and Methods, MRI Acquisition and Image Processing |
| Subjects | vendor=siemens | 28 | lombardo2012 Materials and Methods, MRI Acquisition and Image Processing |
| Subjects | country=GB Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge | 28 | lombardo2012 Materials and Methods, MRI Acquisition and Image Processing |
| Mean age | total | 9.5 | lombardo2012 Materials and Methods, Participants |
| Age SD | total | 0.9 | lombardo2012 Materials and Methods, Participants |
| Minimum age | total | 8 | lombardo2012 Materials and Methods, Participants |
| Maximum age | total | 11 | lombardo2012 Materials and Methods, Participants |
Sources
The keys used in the table above.
- lombardo2012 Lombardo et al. 2012, J Neurosci 32(2) 674-680 (author manuscript PMC3306238) paper
- arc-ft-project Autism Research Centre project page, Prenatal sex steroid hormones and autism website