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Cambridge Foetal Testosterone (CAM-FT) study, MRI cohort

Cambridge Foetal Testosterone longitudinal study, structural MRI cohort of 8 to 11 year old boys

Structural brain MRI of typically developing boys whose testosterone was measured in amniotic fluid before birth, used to relate prenatal testosterone to regional grey matter volume. 28 boys aged 8 to 11 from Cambridgeshire. Not publicly shared.

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Overview

The Cambridge Foetal Testosterone (CAM-FT) study at the Autism Research Centre, University of Cambridge, follows children whose mothers had amniocentesis during pregnancy, so that hormone levels measured in the amniotic fluid can be related to the child's later behaviour, cognition and brain. Its structural MRI cohort of school-age boys was used to show that higher foetal testosterone goes with more grey matter in some sexually dimorphic regions and less in others. The images are not public.

Composition

28 typically developing boys, mean age 9.5 years (SD 0.92, range 8 to 11), one T1-weighted scan each. 22 of the 28 were right-handed. Their mothers had amniocentesis in Cambridgeshire between 1996 and 1999; records were screened and pregnancies with chromosomal abnormalities, twins, termination or miscarriage, missing records or clinical advice against contact were excluded, as were children with developmental abnormalities after birth. Foetal testosterone was measured by radioimmunoassay in amniotic fluid taken at 13 to 20 weeks of gestation (mean 0.79 nmol/l, range 0.25 to 1.70). The sampling week is missing for 7 boys.

Acquisition

All scans were acquired at the Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge, on a Siemens Tim Trio 3 T scanner with a 3D MP-RAGE sequence at 1 mm isotropic resolution (TR 2300 ms, TE 2.98 ms).

Annotations

There are no manual labels. Grey matter, white matter and CSF were segmented with SPM8 and age-specific tissue priors, and grey matter maps were normalised with DARTEL for voxel-based morphometry. The per-child foetal testosterone value is the target variable.

Known limitations

  • No public access route, license or data use terms.
  • Small sample of boys only, so sex differences cannot be studied within the cohort.
  • The comparison of boys and girls in the paper used a separate public cohort, not CAM-FT scans.

Cohort

Aggregate numbers from the sources below. Bars are relative to the 28 subjects.

Sex

  • Male 28 100%

Materials and Methods, Participants in Lombardo et al. 2012, J Neurosci 32(2) 674-680 (author manuscript PMC3306238)

Condition

Groups can overlap

  • Healthy control 28 100%

Materials and Methods, Participants in Lombardo et al. 2012, J Neurosci 32(2) 674-680 (author manuscript PMC3306238)

Field strength

  • 3 T 28 100%

Materials and Methods, MRI Acquisition and Image Processing in Lombardo et al. 2012, J Neurosci 32(2) 674-680 (author manuscript PMC3306238)

Age

mean 9.5 ± 0.9, range 8 to 11

No age bins reported.

Materials and Methods, Participants in Lombardo et al. 2012, J Neurosci 32(2) 674-680 (author manuscript PMC3306238)

Contrast / sequence

Groups can overlap

  • T1-weighted 28 100%

Materials and Methods, MRI Acquisition and Image Processing in Lombardo et al. 2012, J Neurosci 32(2) 674-680 (author manuscript PMC3306238)

Scanner vendor

  • Siemens Healthineers 28 100%

Materials and Methods, MRI Acquisition and Image Processing in Lombardo et al. 2012, J Neurosci 32(2) 674-680 (author manuscript PMC3306238)

Country

  • United Kingdom 28 100%

Materials and Methods, MRI Acquisition and Image Processing in Lombardo et al. 2012, J Neurosci 32(2) 674-680 (author manuscript PMC3306238)

License and access

Our reading of the license, not legal advice. Before you use the data, read the original license and confirm that your use is allowed. We take no responsibility for how you use a dataset. Full disclaimer

Access
On request

Ask the authors or the data holder. No published process or terms, and access is at their discretion

Neither the paper nor the Autism Research Centre project page offers access to the images or states how to request them. Any request goes to the authors.

Access page

No published license or data use terms

The data holder has published no license and no data use terms. Any use, sharing or commercial right has to be agreed with the data holder, and nothing can be assumed to be allowed. Default copyright and data protection law still apply.

The paper and the project page publish no license or data use terms for the MRI data.

Original license text Checked 2026-10-08

What you can do

  • Commercial use Not stated
  • Not stated
  • Train ML models Not stated
  • Create derived data Not stated
  • Publish results Not stated

What you can share

  • Share the data Not stated
  • Share derived data Not stated
  • Share trained models Not stated

What you must do

  • Cite or credit Not stated
  • Share alike Not stated
  • Sign an agreement Not stated
  • Ethics approval Not stated
  • Manuscript review Not stated
  • Release code Not stated
  • Return results Not stated
  • Delete after use Not stated

Limits

  • No re-identification Not stated
  • Location limits Not stated

Citation

Lombardo MV, Ashwin E, Auyeung B, Chakrabarti B, Taylor K, Hackett G, Bullmore ET, Baron-Cohen S. Fetal testosterone influences sexually dimorphic gray matter in the human brain. J Neurosci 32(2), 674-680 (2012). doi:10.1523/JNEUROSCI.4389-11.2012

Sources

Every number on this page comes from one of these documents. Each chart names the table or page it is taken from. The raw numbers are in stats.csv.